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Association analyses of DNA polymorphisms in bovine SREBP-1, LXRα,FADS1 genes with fatty acid composition in Canadian commercial crossbred beef steers
(Elsevier, 2013-03)
Two previously reported DNA polymorphisms of sterol regulatory element binding transcription factor 1 (SREBP1) and liver X receptor alpha (LXRα) and two DNA
polymorphisms of fatty acid desaturase 1 (FADS1) were evaluated ...
High-Throughput Sequencing of microRNAs in Peripheral Blood Mononuclear Cells: Identification of Potential Weight Loss Biomarkers
(Public Library of Science (PLoS), 2013)
INTRODUCTION: MicroRNAs (miRNAs) are being increasingly studied in relation to energy metabolism and body composition homeostasis. Indeed, the quantitative analysis of miRNAs expression in different adiposity conditions ...
Biosimilar medicines in dermatology: key aspects
(Bryn Mawr Communications III LLC, 2013-02)
En el artículo se recoge la aplicación de los medicamentos biosimilares biotecnológicos) en patologías dermatológicas.
Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk
(BioMed Central, 2013-01)
Background: Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucose ...
Resveratrol Metabolites Modify Adipokine Expression and Secretion in 3T3-L1 Pre-Adipocytes and Mature Adipocytes
(Public Library of Science, 2013-05)
Objective: Due to the low bioavailability of resveratrol, determining whether its metabolites exert any beneficial effect is an interesting issue.
Methods: 3T3-L1 maturing pre-adipocytes were treated during differentiation ...
Objectively Measured Physical Activity and Sedentary Time during Childhood, Adolescence and Young Adulthood: A Cohort Study
(Public Library of Science (PLoS), 2013-04-23)
Background: To know how moderate-to-vigorous physical activity (MVPA) and sedentary time change across lifespan periods is needed for designing successful lifestyle interventions. We aimed to study changes in objectively ...
Design,optimization and in vivo evaluation of non-viral vectors for gene therapy. Applications in ocular disorders
(2013-09-27)
[EN] Over the past few years and due to biotechnology development, gene therapy has emerged as a promising therapeutic tool because of the use of exogenous nucleic acids as active ingredients. These nucleic acids, i.e. ...
Nanostructured lipid carriers as vehicles for the delivery of poorly water-soluble drugs
(2013-05-28)
El objetivo de esta tesis ha sido el desarrollo de una formulación basada en NLCs para la administración de fármacos poco solubles, tanto por vía oral como por vía intravenosa. Para ello: 1. Se ha llevado a cabo la evaluación ...
Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research
(Hindawi Publishing Corporation, 2013)
There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the ...
Desarrollo de nanopartículas sólidas lipídicas como sistemas de administración de ADN para terapia génica
(2013-10-24)
[EN] This work includes the development, characterization and optimization of a gene delivery system based on solid lipid nanoparticles (SLNs) . Formulations were characterized in terms of particle size , surface charge ...