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Virion Structure and In Vitro Genome Release Mechanism of Dicistrovirus Kashmir Bee Virus
(American Society For Microbiology, 2021-06)
Infections with Kashmir bee virus (KBV) are lethal for honeybees and have been associated with colony collapse disorder. KBV and closely related viruses contribute to the ongoing decline in the number of honeybee colonies ...
Exploring The Role Of Genome And Structural Ions In Preventing Viral Capsid Collapse During Dehydration
(IOP Publishing, 2018-03-14)
Even though viruses evolve mainly in liquid milieu, their horizontal transmission routes often include episodes of dry environment. Along their life cycle, some insect viruses, such as viruses from the Dicistroviridae ...
Adenylate Cyclase Toxin Promotes Internalisation of Integrins and Raft Components and Decreases Macrophage Adhesion Capacity
(Public Library of Science, 2011-02-23)
Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active. The toxin targets phagocytes ...
Bordetella pertussis-en adenilato ziklasa toxina: makrofagoetan eragindako mintz-iragazkortasun eta heriotz-zelularraren ikerketa
(2017-05-24)
La toxina adenilato ciclasa(ACT) es uno de los factores de virulencia mas importantes de Bordetella pertussis, la bacteria causante de la tos ferina. ACT tiene dos actividades perjudiciales para la celul la actividad ...
The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
(Nature, 2022)
The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to ...
A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines
(Nature Publishing, 2018-09-17)
Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects ...
Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate
(Nature Publishing, 2018-04-11)
The chaperone ClpB in bacteria is responsible for the reactivation of aggregated proteins in collaboration with the DnaK system. Association of these chaperones at the aggregate surface stimulates ATP hydrolysis, which ...
Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens
(MDPI, 2021-08-26)
Prostate cancer (PCa) is one of the most prevalent cancers in men. Androgen receptor signaling plays a major role in this disease, and androgen deprivation therapy is a common therapeutic strategy in recurrent disease. ...
Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer
(Nature Publishing Group, 2018-10-11)
The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity ...
Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity
(Public Library Science, 2014-10-20)
Background: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although ...