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NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation
(Frontiers Research Foundation, 2013-12-18)
Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ...
GABA release by hippocampal astrocytes
(Frontiers Res Found, 2012-08-17)
Astrocytes can directly influence neuronal activity through the release of various transmitters acting on membrane receptors expressed by neurons. However, in contrast to glutamate and ATP for instance, the release of GABA ...
A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report
(BioMed Central, 2010-10)
Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are ...
Role of Monoubiquitylation on the Control of IκBα Degradation and NF-κB Activity
(Public Library of Science, 2011-10-12)
The NF-κB pathway is regulated by multiple post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. Many of these modifications act on the natural inhibitor IκBα modulating its capacity ...
Enfermedad de Parkinson por mutación vasca de la dardarina (LRRK2): estudio epidemiológico, clínico y genético
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2012-06-22)
La genética ha cobrado un papel primordial en la etiopatogenia de la enfermedad de Parkinson (EP), especialmente tras el descrubrimiento en 2004 de las primeras mutaciones en el gen LRRK2, que codifica la proteína denominada ...
FTY720 attenuates excitotoxicity and neuroinflammation
(BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...
Early Medial Temporal Atrophy Scale (EMTA)
(2015-12-30)
[ES]La atrofia del lóbulo temporal medial puede ser medida a través del uso de escalas de atrofia visual tales como la escala de atrofia del lóbulo temporal medial (MTA). La escala MTA ha sido diseñada y validada para el ...
Demencia frontotemporal por mutaciones en el gen de la progranulina. Aspectos clínicos y moleculares
(2016-10-28)
La demencia frontotemporal (DFT) comprende un grupo de enfermedades neurodegenerativas, clínica y neuropatológicamente heterogéneo, que se agrupan por la afectación predominante de los lóbulos frontal y temporal del cerebro, ...
Características neuropsicológicas de pacientes con Enfermedad de Parkinson y portadores asintomáticos de la mutación R1441G en el gen LRRK2
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2015-12-18)
El objetivo de esta tesis es conocer la afectación cognitiva asociada a la mutación LRRK2 R1441G tanto en pacientes con EP, como en portadores asintomáticos de la misma y la posible correlación de esta afectación con el ...
Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases
(BioMed Central, 2010-11-25)
Background
Methylthioadenosine (MTA) has anti-oxidant and anti-proliferative properties and was shown to induce cell protection in hepatic cells. We previously demonstrated that exert immunomodulatory and neuroprotective ...