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Now showing items 11-20 of 20
Morphofunctional changes in a rat model of Parkinson's disease - Effects of neurotrophic factors administration
(2015-10-02)
La investigación actual se basa en la búsqueda de estrategias terapéuticas que consigan detener el proceso neurodegenerativo de la enfermedad de Parkinson. Por tanto, la administración de factores neurotróficos puede ser ...
Revisión sistemática y metanálisis multivariado de la eficacia de potenciadores cognitivos en esquizofrenia
(2015-12-21)
La esquizofrenia es la enfermedad mental más grave y persistente y engloba al 90% de los primeros episodios psicóticos. Por otra parte los pacientes que sufren esta enfermedad tienen peores capacidades cognitivas que la ...
Pio del Rio Hortega and the discovery of the oligodendrocytes
(Frontiers Research Foundation, 2015-07-07)
Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ...
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
(Public Library Science, 2015-12-15)
Cannabinoid CB1 receptors peripherally modulate energy metabolism. Here, we investigated the role of CB1 receptors in the expression of glucose/pyruvate/tricarboxylic acid (TCA) metabolism in rat abdominal muscle. ...
Visualization by High Resolution Immunoelectron Microscopy of the Transient Receptor Potential Vanilloid-1 at Inhibitory Synapses of the Mouse Dentate Gyrus
(Public Library Science, 2015-03-16)
We have recently shown that the transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel in the peripheral and central nervous system, is localized at postsynaptic sites of the excitatory ...
Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis
(Public Library Science, 2015-04-15)
Background
Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...
FTY720 attenuates excitotoxicity and neuroinflammation
(BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...
Early Medial Temporal Atrophy Scale (EMTA)
(2015-12-30)
[ES]La atrofia del lóbulo temporal medial puede ser medida a través del uso de escalas de atrofia visual tales como la escala de atrofia del lóbulo temporal medial (MTA). La escala MTA ha sido diseñada y validada para el ...
Características neuropsicológicas de pacientes con Enfermedad de Parkinson y portadores asintomáticos de la mutación R1441G en el gen LRRK2
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2015-12-18)
El objetivo de esta tesis es conocer la afectación cognitiva asociada a la mutación LRRK2 R1441G tanto en pacientes con EP, como en portadores asintomáticos de la misma y la posible correlación de esta afectación con el ...
A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis
(Oxford University Pres, 2015-10-01)
Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been associated with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (CLL). To determine the causal polymorphism, ...