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Role of amyloid B oligomers in oligodendrocyte and myelin pathology in Alzheimers's disease
(2018-01-18)
La enfermedad de Alzheimer (EA) es un desorden neurodegenerativo caracterizado por la presencia de placas seniles compuestas por agregados del péptido beta amiloide (Aß), siendo las formas solubles las que mejor correlacionan ...
How aging, seizures and ATP change the intrinsic properties of adult hippocampal neural stem cells.
(2018-12-14)
El hipocampo del cerebro de la mayoría de los mamíferos, incluyendo humanos, es capaz de generar nuevas neuronas a partir de de células madre neurales (NSCs) lo largo de la vida adulta mediante un proceso llamado neurogénesis ...
Perspective: Of Mice and Men - How Widespread Is Adult Neurogenesis?
(Frontiers Media, 2019-08-29)
These are exciting times for research on adult hippocampal neurogenesis (AHN). Debate and controversy regarding the existence of generation of new neurons in the adult, and even diseased human brain flourishes as articles ...
Identification of ncRNAs as Potential Therapeutic Targets in Multiple Sclerosis Through Differential ncRNA – mRNA Network Analysis
(Biomed Central, 2015-03-28)
Background: Several studies have revealed a potential role for both small nucleolar RNAs (snoRNAs) and microRNAs (miRNAs) in the physiopathology of relapsing-remitting multiple sclerosis (RRMS). This potential implication ...
Delayed Diagnosis of an Eating Disorder in a Male Patient With Superior Mesenteric Artery Syndrome: Results From a Case Study
(Frontiers Media, 2019-10-15)
Background: Eating disorders (EDs) are serious and life-threatening mental diseases characterized by abnormal or altered eating habits. The prevalence is variable, being influenced by diverse sociocultural factors. ...
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin
(Impact Journals, 2020-04-15)
Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration. The broad phenotypes observed in patients with DM1 ...
Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis
(Oxford University Press, 2020-05)
Dmrt5 (Dmrta2) and Dmrt3 are key regulators of cortical patterning and progenitor proliferation and differentiation. In this study, we show an altered apical to intermediate progenitor transition, with a delay in SP ...
Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain
(Springer, 2019-06-20)
A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important ...
Myelin imaging and characterization by magnetic resonance imaging
(2019-12-13)
Los axones neuronales están recubiertos de una membrana lipídica llamada mielina, que protege a los axones y posibilita una transmisión rápida y eficiente del impulso eléctrico. En ciertas patologías como la lesión cerebral ...
Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus
(Wiley, 2019-08)
Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal ...