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Novel Golden Lipid Nanoparticles with Small Interference Ribonucleic Acid for Substrate Reduction Therapy in Fabry Disease
(MDPI, 2023-07-12)
Substrate reduction therapy (SRT) has been proposed as a new gene therapy for Fabry disease (FD) to prevent the formation of globotriaosylceramide (Gb3). Nanomedicines containing different siRNA targeted to Gb3 synthase ...
Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes
(MDPI, 2023-06-15)
Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition ...
Beneficial Effects of Opuntia spp. on Liver Health
(MDPI, 2023-05-29)
The genus Opuntia spp. includes plants capable of growing in arid, temperate and tropical climates. The vast majority of wild species grow in Mexico, but O. ficus-indica (prickly pear or nopal) is cultivated around the ...
Computational and Experimental Evaluation of the Immune Response of Neoantigens for Personalized Vaccine Design
(MDPI, 2023-05-19)
In the last few years, the importance of neoantigens in the development of personalized antitumor vaccines has increased remarkably. In order to study whether bioinformatic tools are effective in detecting neoantigens that ...
Stability of Monoclonal Antibodies as Solid Formulation for Auto-Injectors: A Pilot Study
(MDPI, 2023-07-30)
Drug adherence is a significant medical issue, often responsible for sub-optimal outcomes during the treatment of chronic diseases such as rheumatoid or psoriatic arthritis. Monoclonal antibodies (which are exclusively ...
Evaluation of the biophysical performance upon the integration of helper components into cationic niosomes for the treatment of both retinal and brain diseases by genetherapy approach
(2023-06-29)
The integration of novel compounds into formulations may open up new avenues and opportunities for improving the treatment of various diseases using a genetherapytechnique. To this purpose, my thesis aimed to study the ...
Assessment of Different Niosome Formulations for Optogenetic Applications: Morphological and Electrophysiological Effects
(MDPI, 2023-07-01)
Gene therapy and optogenetics are becoming promising tools for treating several nervous system pathologies. Currently, most of these approaches use viral vectors to transport the genetic material inside the cells, but ...
Valoración de subproductos de la industria alimentaria mediante fermentación sólida y sumergida con Rhizopus sp.
(2019-03-03)
Se estima que entre un 20 y un 30 % del total de alimentos producidos en Europa se pierde o desperdicia, generando impactos negativos en toda la cadena de suministro de alimentos con unos costes asociados alrededor de 143 ...
Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses
(Elsevier, 2023-04)
Subunit vaccines typically require co-administration with an adjuvant to elicit protective immunity, adding development hurdles that can impede rapid pandemic responses. To circumvent the need for adjuvant in a severe acute ...
Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies
(Baishideng, 2023)
BACKGROUNDDietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic ...