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DLK1 and DLK2 characterization in mouse salivary gland development
(2015-12-11)
Organogenesia seinalizazio bide ezberdinez gidatutako prozesu konplexua da. Askotan organu ezberdinen garapena seinalizazio faktore berdinez dago erregulatuta. Gainera, seinalizazio bideen ikerketa garapena ezagutarazteko ...
Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors
(MDPI, 2022-02-25)
Proprotein convertases or PCs are known to regulate the malignant phenotype of colon cancer cells by different mechanisms, but their effects on cancer stem cells (CSCs) have been less widely investigated. Here, we report ...
Neuroprotective effects of resveratrol and docosahexaenoic acid antioxidants in perinatal hypoxic-ischemic brain injury in rats
(2015-12-11)
Umeen erikortasun eta hilkortasunaren kausa nagusienetariko bat hipoxia-iskemia perinatala da, hortazbere aurkako estrategia neurobabesle berri eta eraginkorragoak aurkitzearen premia. Zentzu honetanerresberatrola eta azido ...
Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia–Ischemia
(MDPI, 2020-02-14)
In the process of neonatal encephalopathy, oxidative stress and neuroinflammation have a prominent role after perinatal asphyxia. With the exception of therapeutic hypothermia, no therapeutic interventions are available ...
Cytocompatibility and Suitability of Protein-Based Biomaterials as Potential Candidates for Corneal Tissue Engineering
(MDPI, 2021-03-31)
The vision impairments suffered by millions of people worldwide and the shortage of corneal donors show the need of substitutes that mimic native tissue to promote cell growth and subsequent tissue regeneration. The current ...
Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia
(MDPI AG, 2013-04-29)
One of the most common causes of mortality and morbidity in children is perinatal hypoxia-ischemia (HI). In spite of the advances in neonatology, its incidence is not diminishing, generating a pediatric population that ...
Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc−/− globozoospermic spermatogenesis
(Wiley, 2022-04)
[EN] Globozoospermia is a type of teratozoospermia characterized by round morphology of the sperm head. Gopc(-/-) infertile globozoospermic murine model has failures during spermiogenesis, such as the incorrect biogenesis ...
Computational predictive modeling of integrated cerebral metabolism, electrophysiology and hemodynamics.
(2019-02-12)
Understanding the energetic requirement of brain cells during resting state and during high neural activity is a very active research area where mathematical models have contributed significantly by providing a context for ...
The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer
(MDPI, 2022-09-20)
The endocannabinoid system is widespread through the body and carries out a wide variety of functions. However, its involvement in other pathologies, such as cancer, still needs further attention. We aim to investigate the ...
Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases
(Impact Journals, 2020-06-15)
Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and high mortality rate. Despite early screening programs, more than half of CRC patients are diagnosed at advanced stages. ...