Examinar por departamento (eus.) "Neurozientziak"
Now showing items 21-40 of 499
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Acetylome in Human Fibroblasts From Parkinson's Disease Patients
(Frontiers Media SA, 2018-04-17)Parkinson's disease (PD) is amultifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most ... -
Adaptación de un sistema de propagación de priones in vitro para el cribado masivo de compuestos específicos frente a las Encefalopatías Espongiformes Transmisibles humanas
(2020-09-11)Las Encefalopatías Espongiformes Transmisibles (EET) son un conjunto de desórdenes neurodegenerativos mortales que afectan a varios mamíferos incluidos los humanos, cuyo agente causante es una isoforma anormalmente plegada ... -
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model : mechanism for deficient glutamatergic transmission?
(BioMed Central, 2011-07-30)Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal ... -
Age‐related cognitive decline in myotonic dystrophy type 1: An 11‐year longitudinal follow‐up study
(Wiley, 2020-03)Background Myotonic dystrophy type 1 (DM1) is an inherited multi-systemic disease involving the central nervous system (CNS) and is consequently characterized by a range of cognitive impairments. However, whether this ... -
AHK konposatuen efikazia duchenne muskulu-distrofiaren animalia-ereduetan
(2019-12-18)Duchenne muskulu-distrofia (DMD) gaixotasun neuromuskular larria da eta X kromosoman dagoen distrofinaren geneko mutazio azpirakorrak dira erantzuleak. 3500 mutiletik bati eragiten dio batez beste eta, gaur egun, sendabiderik ... -
Alteraciones en la Neurogénesis Adulta en Modelos Murinos de Epilepsia del Lóbulo Temporal y potenciales Estrategias Terapéuticas Centradas en la Gliosis
(2024-05-31)El cerebro de la mayoría de las especies de mamíferos es capaz de generar nuevas neuronas a lo largo de la vida adulta; mediante un proceso denominado neurogénesis adulta. La acumulación de evidencias en los últimos años, ... -
Alterations of Oligodendrocyte and Myelin Energy Metabolism in Multiple Sclerosis
(MDPI, 2023-08-18)Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system (CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a vital role in maintaining the integrity of myelin, ... -
Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
(Frontiers Media, 2020-07-21)Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe ... -
Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy
(Nature Publishing Group, 2014-05)Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-beta precursor protein-alpha has been shown to be ... -
Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
(Frontiers Media, 2021-02-03)Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's disease (AD). Due to the many limitations to study microglia ... -
Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease
(SpringerNature, 2022-03-19)[EN] Amyloid beta (Abeta)-mediated synapse dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and previous studies suggest that NMDA receptor (NMDAR) dysregulation may contribute to these pathological ... -
Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach
(Wolters Kluwer, 2019-02)Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to ... -
An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial
(Frontiers Media, 2020)Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable ... -
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
(Genetics Society of America, 2016-07-01)Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) ... -
Anatomical Characterization of the Type-1 cannabinoid receptors in specific brain cell populations of mutant mice
(2016-12-02)The Cannabinoid Type I receptor protein (CB1) expression in the hippocampus of rescue mice modified to express the gene exclusively in specific brain cell types: such as dorsal telencephalic glutamatergic neurons, or ... -
Análisis del discurso de un grupo de adolescentes con trastorno de conducta tras haber participado en el entrenamiento en Habilidades Psicosociales de Terapia Dialéctica Conductual: una investigación
(2017-11-27)INTRODUCCIÓN: En los últimos años han aparecido investigaciones de índole cuantitativa que evalúan la efectividad de la Terapia Dialéctica Conductual (TDC) en adolescentes con problemas de impulsividad y/o desregulación ... -
Análisis exploratorio de la influencia sobre dimensiones de personalidad de polimorfismos genéticos funcionales de la catecol-o-metiltransferasa, el transportador de serotonina y la monoamino oxidasa-A, y su interacción con variables ambientales adversas. Un estudio en pacientes con trastornos de la personalidad y controles sanos
(2019-01-22)Se estudia el efecto de polimorfismos genéticos funcionales de la catecol-o-metil transferasa (COMT), del trasportador de serotonina y de la monoamino oxidasa-A (MAO-A) sobre dimensiones de la personalidad, según el modelo ... -
Annual Research Review: Prevention of Psychosis in Adolescents - Systematic Review and Meta-Analysis of Advances in Detection, Prognosis and Intervention
(Wiley, 2021-05)Background The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less ... -
Antioxidant defense system and family environment in adolescents with family history of psychosis
(BioMed Central, 2012-11-16)[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with ... -
Apego y trastornos mentales graves
(2021-11-26)La hipótesis del continuum de la psicosis defiende que tanto sujetos de la población general, como pacientes con un trastorno de personalidad (TLP) o un brote psicótico manifiesto, comparten características cognitivas, ...