Examinar por departamento (eus.) "Kimika organikoa I"
Now showing items 41-60 of 207
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Brønsted based catalyzed Michael additions for the production of heterocyclic compounds of biological interest
(2023-05-22)Introducimos dos pronucleófilos, 1H-imidazol-4(5H)-onas y pirrolo[1,2-a]pirazin-4(3H)-onas, los cuales cumplen los requerimientos para actuar eficientemente en reacciones organocatalizadas y permitir su posterior ... -
Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(II) and copper(II) complex
(Royal Society of Chemistry, 2017-08-11)A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of the double ... -
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Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes
(MDPI, 2023-03-16)Aldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, ... -
Catalytic Enantioselective Synthesis of Tertiary Thiols From 5H-Thiazol-4-ones and Nitroolefins: Bifunctional Ureidopeptide-Based Brønsted Base Catalysis
(WILEY-VCH Verlag, 2013-09-17)The direct catalytic reaction between an enolizable carbonyl compound and an electrophile under proton-transfer conditions has emerged as a challenging versatile transformation in organic synthesis.1 Over the last years ... -
Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma
(MDPI, 2023-02-14)Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemo/radiotherapy. ... -
Chemoenzymatic synthesis and immunological studies of Xylosylated N-glycans
(2016-06-07)Glycosylation is one of the most common post-translational modifications in eukaryotic cells. It changes during cell development and differentiation and it is tissue and more importantly, species specific. While core ¿-1,6 ... -
Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor
(Beilstein Institut, 2011-07)The synthesis of a GSK 2(nd) generation inhibitor of the hepatitis C virus, by enantioselective 1,3-dipolar cycloaddition between a leucine derived iminoester and tert-butyl acrylate, was studied. The comparison between ... -
Chiral self-recognition in a bispericyclic cyclodimerisation reaction of 1-azadienes
(RSC, 2023-10)Hermaphroditism of molecules: as in nature some species behave as male or female depending on the environment, herein we report a bispericyclic dimerisation of cyclic 1-azadienes where a molecule can behave as either diene ... -
Ciclopéptidos b-lactámicos de tipo rgd: síntesis, estudio conformacional, actividad biológica y análisis génico
(Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2012-07-09)La Tesis que se resume a continuación se engloba dentro de la síntesis de ciclopéptidos ß-lactámicos que presentan la triada RGD (arg-gly-asp) en su estructura. En este caso los ciclopéptidos sintetizados presentan una ... -
Co-Catalyzed C(sp3)−H Oxidative Coupling of Glycine and Peptide Derivatives
(American Chemical Society, 2017-09-22)obalt-catalyzed selectiveα-alkylation andα-heteroarylation processes ofα-amino esters and peptide derivativesare described. These cross-dehydrogenative reactions occur undermild conditions and allow for the rapid assembly ... -
Computational Methods Applied to Transition Metal Catalysis and Pericyclic Reactions
(2020-07-10)La presente tesis consiste en una serie de estudios realizados en el marco de la química computacional. La teoría del funcional de la densidad ha sido aplicada para la simulación de diversas reacciones químicas. Mediante ... -
Computational understanding of heterocyclisation reactions and synthesis of fluorinated isoquinolines
(2020-11-27)The present thesis deals with three different topics that have in common the formation of carbo- and heterocycles. The whole work is organized as a synergy of experimental and computational studies to provide a deep ... -
Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp(3) C-O Bonds in Cyclic Acetals
(American Chemical Society, 2022)A dual catalytic manifold that enables site-selective functionalization of unactivated sp(3) C-O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate sigma*-p orbital ... -
Cross-Dehydrogenative Coupling Reactions for the Functionalization of α-Amino Acid Derivatives and Peptides
(Georg Thieme Verlag, 2018-06-25)The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic ... -
Cu-Catalyzed Site-Selective C(sp2)–H Radical Trifluoromethylation of Tryptophan Containing Peptides
(ACS Publications, 2020-02-13)Site-selective functionalization of C–H bonds within a peptide framework poses a challenging task of paramount synthetic relevance. Herein, we report an operationally simple C(sp2)–H trifluoromethylation of tryptophan ... -
Cyclotryptophan Mycotoxins: Short Synthesis of the Desymmetrized meso-Chimonantine Core of Leptosin C
(Georg Thieme, 2016-12-01)The desymmetrized meso-chimonantine core of leptosin C was prepared in a short stereoselective convergent sequence in 5 steps as the longest linear path from methyl l-tryptophan hydrochloride as starting material. The key ... -
Dehydration of alcohols catalyzed by copper(ii) sulfate: type II dyotropic reactions and stepwise mechanisms
(RSC, 2024)Dehydration of alcohols in the presence of copper(II) sulfate has been analyzed computationally. Density functional theory (DFT) calculations on selected alcohols indicate that this reaction can take place via two possible ... -
Design and Chemical Synthesis of Fluorescent Bicolor Indicators for the Detection of Neutrinoless Double Beta Decay of 136Xe
(2022-11-11)La observación de la desintegración beta doble sin neutrinos (¿¿¿¿) demostraría que el neutrino es una partícula de Majorana, es decir, su propia antipartícula. Este proceso de desintegración sólo es posible en algunos ... -
Design and Evaluation of New Phosphorus Substituted Aziridines as Antiproliferative Agents
(MDPI, 2019-08-09)Covalent bond formation has become a safe and effective strategy applied not only by nature but also by the pharmaceutical industry to improve disease pharmacology. In the history of modern medicine, covalent drugs have ...