Browsing by Author "Yamamura, Takashi"

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      A 4-Trifluoromethyl Analogue of Celecoxib Inhibits Arthritis by Suppressing Innate Immune Cell Activation 

      Chiba, Asako; Mizuno, Miho; Tomi, Chiharu; Tajima, Ryohsuke; Alloza Moral, Iraide; Di Penta, Alessandra; Yamamura, Takashi; Vandenbroeck, Koen; Miyake, Sachiko (Biomed Central, 2012-01-17)
      Introduction: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. ...
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      A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation 

      Di Penta, Alessandra; Chiba, Asako; Alloza Moral, Iraide; Wyssenbach Ibarra, Ane; Yamamura, Takashi; Villoslada, Pablo; Miyake, Sachiko; Vandenbroeck, Koen (Public Library of Science, 2013-12-11)
      Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving ...