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Multivalency Transforms SARS-CoV-2 Antibodies Into Ultrapotent Neutralizers
(Nature, 2021-06-16)SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin protomer as a modular subunit to drive ... -
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
(Biomed Central, 2016-11-18)Background: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is ... -
Naked Eye Y Amelogenin Gene Fragment Detection Using DNAzymes on a Paper-based Device
Azuaje Hualde, Enrique
; Arroyo Jiménez, Susana; Garai Ibabe, Gaizka; Benito López, Fernando ; Martínez de Pancorbo Gómez, María de los Angeles (Elsevier, 2020-05-07)
Nowadays, there are strong efforts in developing new technology for rapid detection of specific DNA sequences for environmental monitoring, forensic analysis and rapid biomedical diagnosis applications. That is where ... -
Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy
Plou, Javier; Molina Martínez, Beatriz; García Astrain, Clara; Langer, Judith; García, Isabel; Ercilla, Amaia; Perumal, Govindaraj; Carracedo Pérez, Arkaitz; Liz Marzán, Luis Manuel (American Chemical Society, 2021-10-27)
[EN]Monitoring dynamic processes in complex cellular environments requires the integration of uniformly distributed detectors within such three-dimensional (3D) networks, to an extent that the sensor could provide real-time ... -
Nanofocusing of acoustic graphene plasmon polaritons for enhancing mid-infrared molecular fingerprints
(De Gruyter, 2020)Mid-infrared (mid-IR) optical spectroscopy of molecules is of large interest in physics, chemistry, and biology. However, probing nanometric volumes of molecules is challenging because of the strong mismatch of their ... -
Nanometer-Scale Lateral p–n Junctions in Graphene/α-RuCl3 Heterostructures
(American Chemical Society, 2022)[EN] The ability to create nanometer-scale lateral p-n junctions is essential for the next generation of two-dimensional (2D) devices. Using the charge-transfer heterostructure graphene/alpha-RuCl3, we realize nanoscale ... -
Nanostructural Organization of Thin Films Prepared by Sequential Dip-Coating Deposition of Poly(Butylene Succinate), Poly(ε-Caprolactone) and Their Copolyesters (PBS-ran-PCL)
Peñas Núñez, Mario Iván; Ocando, Connie; Penott Chang, Evis; Safari, Maryam; Ezquerra, Tiberio A.; Rebollar, Esther; Nogales, Aurora; Hernández, Rebeca; Müller Sánchez, Alejandro Jesús (Elsevier, 2021-06-04)
In this work, we prepare and characterize multiphasic thin films containing poly(epsilon-caprolactone), PCL, poly (butylene succinate), PBS, and a poly (butylene succinate-ran-epsilon-caprolactone) (PBS-ran-PCL) random ... -
Natural insurance as condition for market insurance: Climate change adaptation in agriculture
(Elsevier, 2020)This paper focuses on the potential use of insurance as a climate change adaptation mechanism in agriculture. We analyse the attractiveness of a climate risk insurance scheme and the choices farmers face between adaptation ... -
Nd3+-Doped Lanthanum Oxychloride Nanocrystals as Nanothermometers
(American Chemical Society, 2021-09-16)The development of optical nanothermometers operating in the near-infrared (NIR) is of high relevance toward temperature measurements in biological systems. We propose herein the use of Nd3+-doped lanthanum oxychloride ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ... -
Nematicity Arising from a Chiral Superconducting Ground State in Magic-Angle Twisted Bilayer Graphene under In-Plane Magnetic Fields
(American Physical Society, 2021-09-13)Recent measurements of the resistivity in magic-angle twisted bilayer graphene near the superconducting transition temperature show twofold anisotropy, or nematicity, when changing the direction of an in-plane magnetic ... -
Network dynamics in nanofilled polymers
Baeza, Guilhem P; Dessi, Claudia; Costanzo, Salvatore; Zhao, Dan; Gong, Shushan; Alegría Loinaz, Angel María; Colb, Ralph H.; Rubinstein, Michael; Vlassopoulos, Dimitris; Kumar, Sanat K. (Nature Publishing, 2016-04-25)
It is well accepted that adding nanoparticles (NPs) to polymer melts can result in significant property improvements. Here we focus on the causes of mechanical reinforcement and present rheological measurements on favourably ... -
New trends in catalysis for sustainable CO2 conversion
(MDPI, 2022-10-23)Over the past few decades, there have been many advances in the world, leading to improvements in quality of life. Due to demographic and industrial growth, consumption has increased, as well as the amount of waste and ... -
Nitrogen Source and External Medium pH Interaction Differentially Affects Root and Shoot Metabolism in Arabidopsis
(Frontiers Media, 2016-02-01)Ammonium nutrition often represents an important growth-limiting stress in plants. Some of the symptoms that plants present under ammonium nutrition have been associated with pH deregulation, in fact external medium pH ... -
Non-Intrusive Assessment of COVID-19 Lockdown Follow-Up and Impact Using Credit Card Information: Case Study in Chile
(MDPI, 2021-05-21)In this paper, we propose and validate with data extracted from the city of Santiago, capital of Chile, a methodology to assess the actual impact of lockdown measures based on the anonymized and geolocated data from credit ... -
Non-invasive diagnosis of viability in seeds and lichens by infrared thermography under controlled environmental conditions
Fernández Marín, Beatriz; Buchner, Othmar; Kastberger, Gerald; Piombino, Federica; García Plazaola, José Ignacio; Kranner, Ilse (BMC, 2019-12)
Background: Non-invasive procedures for the diagnosis of viability of plant or fungal tissues would be valuable for scientific, industrial and biomonitoring purposes. Previous studies showed that infrared thermography (IRT) ... -
Non-Isocyanate Polyurethane Soft Nanoparticles Obtained by Surfactant-Assisted Interfacial Polymerization
(ACS, 2017-01-24)Polyurethanes (PUs) are considered ideal candidates for drug delivery applications due to their easy synthesis, excellent mechanical properties, and biodegradability. Unfortunately, methods for preparing well-defined PU ... -
Non-Linear Optical Properties of Er3+–Yb3+-Doped NaGdF4 Nanostructured Glass–Ceramics
; ; Balda de la Cruz, Rolindes; ; ; ; (MDPI, 2020-07-21)
Transparent oxyfluoride glass–ceramics containing NaGdF4 nanocrystals were prepared by melt-quenching and doped with Er3+ (0.5 mol%) and different amounts of Yb3+ (0–2 mol%). The selected dopant concentration the crystallization ... -
Noncollinearity in dijet fragmentation in electron-positron scattering
(American Physical Society, 2019-08-09)We study fragmentation in electron-positron annihilation assuming a dijet situation, using variables defined independent of any frame. In a collinear situation some of the variables are centered around zero with the small ... -
Normal and Anomalous Self-Healing Mechanism of Crystalline Calcium Silicate Hydrates
Dupuis, Romain; Moon, Juhyuk; Jeong, Yeonung; Taylor, Rae; Kang, Sung Hoon; Manzano Moro, Hegoi; Ayuela Fernández, Andrés; Monteiro, Paulo J. M.; Sánchez Dolado, Jorge (Elsevier, 2021-04)
The origin of different stability of crystalline calcium silicate hydrates was investigated. The tobermorite crystal has been used as an analog of cement hydrate that is being mostly manufactured material on earth. Normal ...