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      Hypoxia Reduces Cell Attachment of SARS-CoV-2 Spike Protein by Modulating the Expression of ACE2, Neuropilin-1, Syndecan-1 and Cellular Heparan Sulfate 

      Prieto Fernández, Endika; Egia Mendikute, Leire; Vila Vecilla, Laura; Bosch, Alexandre; Barreira Manrique, Adrián; Lee, So Young; García del Río, Ana; Antoñana Vildosola, Asier; Jiménez Lasheras, Borja; Moreno Cugnon, Leire; Jiménez Barbero, Jesús ORCID; Berra Ramírez, Miren Edurne; Ereño Orbea, June; Palazón, Asís (Taylor & Francis, 2021-06-06)
      A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to ...
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      PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer 

      Zabala Letona, Amaia; Arruabarrena Aristorena, Amaia; Fernández Ruiz, Sonia; Viera, Cristina; Carlevaris, Onintza; Ercilla Eguiarte, Amaia; Mendizabal, Isabel; Martín Mateos, Teresa; Macchia, Alice; Camacho Soguero, Laura; Pujana Vaquerizo, Mikel; Sánchez Mosquera, Pilar; Torrano Moya, Verónica; Martín Martín, Natalia; Zuñiga García, Patricia; Castillo Martín, Mireia; Ugalde Olano, Aitziber; Loizaga Iriarte, Ana; Unda Urzaiz, Jesús Miguel; Mato, José M.; Berra Ramírez, Miren Edurne; Martínez Chantar, María Luz ORCID; Carracedo Pérez, Arkaitz ORCID (Springer Nature, 2022-02)
      [EN] Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as a prostate cancer biomarker. This enzyme is predominantly ...