VolverExaminar OpenAire por departamento (cas.) "Inmunología, microbiología y parasitología"
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Candida parapsilosis Colony Morphotype Forecasts Biofilm Formation of Clinical Isolates
(MDPI, 2021-01-07)Candida parapsilosis is a frequent cause of fungal bloodstream infections, especially in critically ill neonates or immunocompromised patients. Due to the formation of biofilms, the use of indwelling catheters and other ... -
Cholesterol Constrains the Antigenic Configuration of the Membrane-Proximal Neutralizing HIV-1 Epitope
Torralba Iturbe, Johana
; De la Arada Echevarría, Igor ; ; ; ; ; ; ; Apellaniz Unzalu, Beatriz ; (ACS, 2020-06-25)
The envelope glycoprotein (Env) enables HIV-1 cell entry through fusion of host-cell and viral membranes induced by the transmembrane subunit gp41. Antibodies targeting the C-terminal sequence of the membrane-proximal ... -
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile
; ; ; ; ; ; ; Sánchez Eugenia, Rubén; ; ; ; ; ; ; ; ; (Cell Press, 2021-09-24)
Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the ...