Browsing OpenAire by Author "Palazón, Asís"
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Hypoxia Reduces Cell Attachment of SARS-CoV-2 Spike Protein by Modulating the Expression of ACE2, Neuropilin-1, Syndecan-1 and Cellular Heparan Sulfate
Prieto Fernández, Endika; Egia Mendikute, Leire; Vila Vecilla, Laura; Bosch, Alexandre; Barreira Manrique, Adrián; Lee, So Young; García del Río, Ana; Antoñana Vildosola, Asier; Jiménez Lasheras, Borja; Moreno Cugnon, Leire; Jiménez Barbero, Jesús ; Berra Ramírez, Miren Edurne; Ereño Orbea, June; Palazón, Asís (Taylor & Francis, 2021-06-06)A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to ... -
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
Araujo, Angela M.; Abaurrea, Andrea; Azcoaga, Peio; López Velazco, Joanna I.; Manzano, Sara; Rodríguez Martínez, Javier; Rezola, Ricardo; Egia Mendikute, Leire; Valdés Mora, Fátima; Flores, Juana M.; Jenkins, Liam; Pulido, Laura; Osorio Querejeta, Iñaki; Fernández Nogueira, Patricia; Ferrari, Nicola; Viera, Cristina; Martín Martín, Natalia; Tzankov, Alexandar; Eppenberger Castori, Serenella; Álvarez López, Isabel; Urruticoechea, Ander; Bragado, Paloma; Coleman, Nicholas; Palazón, Asís; Carracedo Pérez, Arkaitz ; Gallego Ortega, David; Calvo González, Fernando; Isacke, Clare M.; Caffarel, María M.; Lawrie, Charles (American Society of Clinical Investigation, 2022-04-01)[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we ... -
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
Lenza, Maria Pia; Oyenarte Santamaría, Iker; Diercks, Tammo; Quintana García, Jon Imanol; Gimeno, Ana; Coelho, Helena; Diniz, Ana; Peccati, Francesca; Delgado, Sandra; Bosch, Alexandre; Valle, Mikel; Millet Aguilar-Galindo, Oscar; Abrescia, Nicola G. A. ; Palazón, Asís; Marcelo, Filipa; Jiménez Oses, Gonzalo; Jiménez Barbero, Jesús ; Ardá, Ana ; Ereño Orbea, June (Wiley, 2020-10)The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed ...