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Physiological modules for generating discrete and rhythmic movements: Component analysis of EMG signals
(Frontiers Research Foundation, 2015-01-09)
A central question in Neuroscience is that of how the nervous system generates the spatiotemporal commands needed to realize complex gestures, such as handwriting. A key postulate is that the central nervous system (CNS) ...
Systematic analysis of chemical-protein interactions from zebrafish embryo by proteome-wide thermal shift assay, bridging the gap between molecular interactions and toxicity pathways
(Elsevier, 2021-10-30)
[EN]The molecular interaction between chemicals and proteins often promotes alteration of cellular function. One of the challenges of the toxicology is to predict the impact of exposure to chemicals. Assessing the impact ...
Liver metastases of intrahepatic Cholangiocarcinoma: implications for an updated staging system
(Wiley, 2021-06-18)
[EN] BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma
(iCCA) with liver metastases is perceived to have a
poor prognosis, but the American Joint Committee on Cancer
(AJCC) classifies them as early stage in the absence ...
Survival of Frail Elderly with Delirium
(MDPI, 2022-02-16)
This study aims to determine when frailty increases the risks of delirium mortality. Hospital patients falling into the elderly frail or pre-frail category were recruited, some without delirium, some with delirium at ...
Adiponectin, leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD
(Frontiers Media, 2021-06-23)
[EN] Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease where liver biopsy remains the gold standard for diagnosis. Here we aimed
to evaluate the role of circulating adiponectin, ...
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
(Elsevier, 2020-01)
PGC-1 alpha controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ...
Mineralocorticoid Receptor Modulation by Dietary Sodium Influences NAFLD Development in Mice
(Elsevier, 2021-04-30)
Introduction and Objectives
Nonalcoholic-fatty-liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Mineralocorticoid receptor (MR) activation is associated with increased risk of ...