Examinar Tesis Doctorales por departamento (cas.) "Farmacología"
Now showing items 21-36 of 36
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Human postmitotic neurons derived from NTERA2/D1 cells by short exposure to cytosine-b-D-Arabinofuranoside: characterization of neurotransmitter phenotypes and role of phospholipase C b1 in differentiation
(2015-07-06)Caracterización fenotípica de neurotransmisores y papel de la fosfolipasa C ß1 en la diferenciación neuronal de células NT2 de teratocarcinoma humano mediante tratamiento con citosina-ß-D-arabinofuranosido (AraC). Antecedentes ... -
Impacto de la falta de adherencia terapéutica sobre la eficacia antimicrobiana de Amoxicilina, Levofloxacino y Moxifloxacino, como probabilidad de alcanzar un índice farmacocinético-farmacodinámico, en pacientes ambulatorios con neumonía adquirida en la comunidad, teniendo en cuenta su variabilidad interindividual.
(2017-07-05)El punto de partida para la realización de este trabajo ha sido la falta de estudios que permitan conocer las consecuencias de la falta de adherencia a la prescripción de la dosificación antimicrobiana sobre su eficacia ... -
In vivo functional role of the 5-HT2A/mGlu2 receptor heterocomplex in rodents
(2018-01-11)La esquizofrenia es una enfermedad prototípica humana de etiología aún desconocida. La investigación con modelos animales permite estudiar las causas y mecanismos afectados en dicha enfermedad. Así, fármacos como el DOI, ... -
Learning and memory improvement mediated by CB1 cannabinoid receptors in animal models of cholinergic dysfunction
(2018-10-26)The selective vulnerability of the basal forebrain cholinergic system (BFCS) is responsible for most of the clinical alterations in learning and memory processes that are characteristic of the Alzheimer¿s disease (AD). The ... -
Molecular mechanisms underlying cannabis abuse and schizophrenia: Focus on 5-HT2A receptors and Akt/mTOR signaling pathway
(2020-07-09)Schizophrenia is a chronic and disabling mental illness that affects around 20 million people worldwide. The etiology of the disorder is multifactorial, and different genetic and environmental factors take part in its onset ... -
Network dynamic of Basal Ganglia circuits in normal and parkinsonian conditions
(2022-12-16)Basal ganglia (BG) circuits are involved in different functions from movement control to cognitive/motivational processes. The loss of dopamine (DA) in these circuits triggers Parkinson's disease (PD). In addition to DA ... -
Neurophysiology of non-motor complications in Parkinson's disease: role of the locus coeruleus.
(2020-05-08)La enfermedad de Parkinson es un trastorno neurodegenerativo, definido inicialmente por sus síntomas motores. Sin embargo, hoy en día la probabilidad de que se trate de un trastorno complejo en lugar de una enfermedad ... -
New insights into the treatment of depression: role of girk channels and the glutamatergic antagonist ketamine in the neurophysiology of the dorsal raphe nucleus
(2015-06-11)The thesis work is focused on the characterization of the neurophysiology of dorsal raphe neurons and the behavioral response in depression-related tests in mice lacking GIRK2 subunits and study of the effect of ketamine ... -
Optimizing pharmacotherapy in the elderly using modelling and simulation methods. Application to Bilastine
(2021-11-29)This research project was designed to acquire a deeper knowledge on how physiological changes during aging mayaffect the pharmacokinetics (PK) and pharmacodynamics (PD). Elderly adults are a vulnerable population due to ... -
Pharmacological characterization of prostaglandin E2 EP receptors in the rodent brain: functional studies in locus coeruleus neurons and the preBötzinger complex
(2019-10-11)This work focuses on the study of the neuropharmacological mechanisms underlying prostaglandin E2 (PGE2) receptor (EP) activation in locus coeruleus (LC) neurons and the preBötzinger complex (preBötC). PGE2 is an inflammatory ... -
Pharmacometric analysis of the in vitro activity of echinocandins, amphotericin B and isavuconazole against Candida Auris
(2021-07-19)C. auris is a multidrug-resistant fungal pathogen that has recently emerged globally as a cause of life-threatening invasive infections. Despite the increasing concern on the reduced treatment options of C. auris infections, ... -
Regulation of electrophysiological effects of opioids by the prostanoid system in the rat locus coeruleus
(2023-07-19)El uso de analgésicos opioides en el tratamiento del dolor está limitado por la aparición de efectos adversos como la tolerancia. Los antiinflamatorios no esteroideos (AINEs), que reducen el dolor y la inflamación mediante ... -
Role of G protein coupled inwardly rectifier K+ channels (GIRK) on the neurobiology depression
(2014-02-11)[EN] Major depression is a recurrent or chronic mood disorder with impaired psychosocial function, and an increased tendency of relapse for patients who fail to reach remission. In industrialized societies, it affects 15% ... -
Sphingosine 1-phosphate (S1P) system in healthy brain and alzheimer's disease
(2021-01-27)The physiological consequences of the super-specialization of the lipids in the different regions and cellular types of the central nervous system (CNS), remain largely being a mystery. In fact, the so-called neurolipids, ... -
Tailored gelatin-based three-dimensional sysems for bone tissue engineering.
(2019-12-17)The current Doctoral Thesis is focused on the development of three-dimensional systems for bone tissue engineering purposes. Gelatin was chosen as the main material to manufacture scaffolds capable for serving as both ... -
The endocannabinoid system in experimental models of Alzheimer's disease
(2017-06-29)Durante la progresión de la enfermedad de Alzheimer (EA) se produce una degeneración del sistema de neurotransmisión colinérgico del prosencéfalo basal, que conduce a una pérdida progresiva e irreversible de funciones ...