Examinar Tesis Doctorales por departamento (eus.) "Biokimika eta biologia molekularra"
Now showing items 81-100 of 130
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Molecular determinants of Kv7.2 surface expression
(2014-02-25)El objetivo de esta tesis ha sido esclarecer las bases moleculares de la expresión en membrana de los canales M neuronales, crucial para una mejor comprensión de su funcionamiento. La densidad de canales en superficie se ... -
Molecular recognition between PCNA and proteins involved in DNA replication and repair: p15 and p12
(2019-12-19)El antígeno nuclear de células en proliferación (PCNA) es un factor esencial en replicación y reparación de ADN en eucariotas. Forma un anillo homotrimérico que rodea y se desliza a lo largo del ADN, actuando como una ... -
Molecular recognition of the HIV-1 neutralizing MPER epitope reconstituted in membranes. Contribution of lipid composition and transmembrane domain inclusion.
(2022-04-08)GIBaren gainazalean kokatzen den Env proteina da birusaren infekzioa hasteko gertatu behar den birusaren eta itu zelularen mintzen arteko fusioa eragiten duena eta immunitate sistemarentzako eskuragarri dagoen proteina ... -
Multifunctionality of membrane remodeling proteins Reticulon and Dynamin 2
(2021-07-15)Los procesos de remodelación de membranas, especialmente aquellos en los que la transformación supone un proceso irreversible, como son la fusión y la fisión, son mecanismos vitales de las células eucariotas para su correcto ... -
NMR-based metabolomics in precision medicine. Application to metabolic syndrome and COVID-19.
(2023-06-15)La medicina de precisión debe considerarse como un enfoque innovador de la medicina tradicional ya que se centra en un tratamiento más personalizado de las patologías de los pacientes en función de sus características ... -
Novel functions of Calmodulin in Kv7.2 regulation and co-translational folding
(2023-07-17)CaM binds to the calcium responsive domain (CRD) of voltage-gated potassium channel 7.2 (Kv7.2), transmitting calcium signaling to control its pore gating. In addition, CaM affects other functions, such as trafficking to ... -
Novel mechanisms for regulation of cell survival and migration by ceramide 1-phosphate
(2014-02-07)Ceramide 1-phosphate is a bioactive sphingolipid that regulates important cell functions, including cell proliferation, apoptosis, migration or inflammation. Cell homeostasis is essential for the normal development of any ... -
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On the effect of cosolutes and crowders in the stability and kinetic properties of proteins
(2022-10-24)[EN]It is known since long time that life is present in every environment on Earth, however, this fact results surprising, since some of such environments are characterized by conditions that seem to be incompatible with ... -
Pathological ATAD3 variants and perturbed cholesterol metabolism in human and fly
(2023-06-22)Among the hundreds of nuclear-encoded components of mitochondria that have been linked to human disease, mutations in the ATAD3 gene cluster have emerged as one of the most frequent in recent years. The ATAD3 locus encodes ... -
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Physical principles underlying structure, mechanics and dynamic re-organization of hyaluronan-rich matrices - from tissues to supramolecular models in experiment and theory
(2016-07-29)The goal of this research project is to understand the physical principles that underlie the structure, mechanics and dynamic reorganization of hyaluronan-rich pericellular and extracellular matrices. Many cells produce a ... -
Promotion of membrane interactions as a pathway for HIV antibody optimization
(2021-01-15)GIBak Env fusio glukoproteina erabiltzen du CD4 hartzailea adierazten duten zelulak infektatzeko. Immunitate sistemari eskuragarri dagoen antigeno bakarra izan arren, Env-ek honi ihes egiteko dituen mekanismoek erantzun ... -
Proteostasis and Rare Diseases: Congenital Erythropoietic Porphyria and Townes-Brocks Syndrome
(2020-07-28)El término proteostasis se refiere a todos aquellos procesos biológicos críticos para el buen funcionamiento de la célula. La alteración de las vías reguladoras de la proteostasis puede afectar seriamente la función celular ... -
Regulación de la actividad chaperona de HSC70 humana por APG2: papel de los dominios divergentes.
(2021-07-29)La reactivación de agregados proteicos en metazoos se logra mediante la actividad combinada de chaperonas de las familias Hsp70, Hsp40 y Hsp110. Apg2 humana estimula la reactivación de agregados ordenados y desordenados ... -
Regulation of cell proliferation and migration by phosphatidic acid and ceramide 1-phosphate. Implication in lung cancer and inflammation
(2023-12-18)According to the World Health Organization (WHO), chronic inflammatory lung diseases, includingasthma, COPD, fibrosis, or lung cancer are among the major causes of death Worldwide. Althoughthese are subjects of intense ... -
Regulation of inflammatory processes by ceramide kinase and phosphatidylethanolamine N-methyltransferase in lung cells, adipocytes and liver tissue.
(2019-05-31)Nowadays, around 60% of the world's population dies due to chronic inflammatory conditions, such as chronic respiratory diseases, obesity, fatty liver disease and cancer. All these pathologies are associated to alterations ... -
Regulation of macrophage and preadipocyte proliferation and migration by C1P
(2022-03-25)Chronic inflammatory diseases are the most significant cause of death in the world. Indeed, according to the World Health Organization (WHO), 3 out of 5 people die due to chronic inflammatory diseases such as stroke, chronic ... -
Regulation of the Hsc70 system by the cochaperone DnaJA2
(2022-02-21)El sistema Hsc70 humano controla funciones esenciales para la viabilidad celular, como la neutralización de conformaciones proteicas mal plegadas y la reactivación de agregados formados cuando la agregación es inevitable. ... -
Repurposing ciclopirox as a pharmacological chaperone active against congenital erythropoietic porphyria.
(2018-10-19)La porfiria eritropoyética congénita es una enfermedad rara autosómica recesiva producida por una actividad deficiente en la uroporfirinógeno III sintasa, la cuarta enzima de la ruta biosintética del grupo hemo. La enfermedad ...