Browsing Tesis Doctorales by Title
Now showing items 1168-1187 of 4316
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Determinantes del capital relacional en la innovación: Una aplicación al sector de automoción español
(2017-10-17)La globalización, la internacionalización, los cambios económicos, sociales y tecnológicos han situado a las empresas en un entorno cada vez más competitivo. Esta situación hace necesario un cambio en el modelo económico ... -
Determination of drugs used in combined cardiovascular therapy
(2012-03-28)Cardiovascular diseases are nowadays the first cause of mortality worldwide, causing around the 30% of global deaths each year. The risk of suffering from cardiovascular illnesses is strongly related to some factors such ... -
Determination of nonlinear optical properties with quantum chemistry: from benchmarks to experimental systems
(2022-12-02)This thesis addresses different aspects related to the computation of nonlinear optical(NLO) properties, from the investigation of reference benchmark systems using highlyaccurate wavefunction methods to that of experimental ... -
Determination of optimal cryoprotectant agents for 3D cell-based products cryopreservation by slow freezing
(2018-12-12)En esta tesis doctoral, se describen y se determinan los crioprotectores clave para la preservación de productos celulares 3D mediante la congelación lenta. Para ello, se han llevado a cabo los siguientes estudios: (i) ... -
Determination of the molecular architecture and the mechanism of self-assembly of Dynamin1 protein machine
(2021-03-26)La Dinamina1 es una GTPasa implicada en el proceso de fisión de membrana durante la endocitosis. Para ello, la Dinamina1 adopta una estructura helicoidal alrededor de los cuellos de membrana. Utilizando la energía de la ... -
Determining the binding kinetics and signalling effects of CB1 and CB2 receptor ligands; a closer look at residence time and functional selectivity
(2022-05-30)The CB1 and CB2 receptors are the main GPCRs of the endocannabinoid system, and regulate many important physiological processed as pain, inflammation, or behaviour. Increasing interest exist to develop new drugs targeting ... -
Developing ferrite based nanocompounds for biomedical applications
(2017-04-11)La falta de especificidad de muchos tratamientos, tales como la quimioterapia o la radioterapia para tratamientos de cáncer, son el mayor obstáculo para la curación de dichas enfermedades. Tales tratamientos suelen requerir ... -
Developing Hole Selective Layers and Implementing Large-size Organic Cations for Perovskite Solar Cells
(2022-09-12)Thesis Abstract Organic-inorganic halide perovskite solar cells(PSCs) have emerged as one of the best candidates in next generation photovoltaics since their introduction in 2009. The power conversion efficiency (PCE) has ... -
Development and application of environmental integrated assessment modelling towards sustainability
(2016-06-03)Los Modelos Ambientales de Evaluación Integrada (MEIs) constituyen una potente herramienta que integra diferentes disciplinas y dimensiones para informar en la toma de decisiones hacia la sostenibilidad. En esta tesis ... -
Development and application of thermal desorption techniques for the measurement of PAHs in ambient air
(2017-02-17)Entre todos los contaminantes, los hidrocarburos aromáticos policíclicos (HAPs) han sido objeto de uninterés creciente en los últimos años. Debido a sus características (propiedades carcinogénicas,mutagénicas e inmunotóxicas) ... -
Development and applications of natural orbital functional theory
(2020-03-31)Desarrollamos la teoría del funcional de orbitales naturales (TFON). En el contexto de laciencia que estudia la estructura electrónica, TFON mantiene la promesa de describir la correlaciónfuerte con el mínimo coste ... -
Development and applications of semicrystalline polymers: from shape memory to self-healing materials
(2017-02-10)Las exigencias y comodidades del día a día hacen que el mundo en el que vivimos sea cada vez más automatizado y tecnológico, habiendo cada vez más interés en tener aparatos y materiales capaces de actuar por sí mismos. En ... -
Development and characterization of exterior Radiata-pine cladding for more sustainable and energy efficient façades in the Basque Country
(2017-04-07)El principal objetivo de esta tesis es estudiar la influencia de los acabados exteriores de madera, a partir de tablas machihembradas, en el comportamiento térmico de fachadas de madera. Para ello, se analiza tanto su ... -
Development and characterization of non-viral vectors based on cationic niosomes to address cystic fibrosis disease by gene therapy approach
(2022-03-17)Gene therapy is based on the delivery of exogenous genetic material into target cells to modulate theexpression of an altered genome in order to treat a specific disease. Lipid nanocarriers, such as niosomesbased on cationic ... -
Development and evaluation of non-viral gene delivery vectors and their combination with hydrogel scaffold technology
(2018-10-26)Nanotechnology-based non-viral vectors have emerged as promising alternatives to viruses to carry genetic material into target cells due to their ability to overcome many limitations of viral vectors. Although very efficient, ... -
Development and implementation of new analytical methodologies for the study of aciditfication in estuaries
(2018-03-09)Siendo la acidificación de los océanos un tema candente en las últimas décadas, muy poco se ha avanzado en lo que acidificación en estuarios se refiere, fundamentalmente en lo relativo al tratamiento de los datos obtenidos ... -
Development and Validation of a Frequency Domain Based Methodology for the Preliminary Design of Floating Offshore Wind Semi-Submersible Platforms
(2023-12-12)Through this Thesis, a novel methodology for the preliminary design of floating offshore wind substructures has been developed. The main advantage is the significantly higher efficient, in terms of computational cost, ... -
Development of a cartilage tissue engineering construct based on hASCs spheroids differentiated under hypoxia in a chitosan/chitin nanocrystals 3D scaffold.
(2019-01-14)The generation of a cartilage tissue engineering (TE) construct is currently a viable strategy for the treatment of osteoarthritis. Such construct requires a biomaterial with optimal properties, including biocompatibility, ... -
Development of a data-driven ageing model for Li-ion batteries: a nonparametric approach to learn from real operation data
(2021-01-25)Li-ioizko bateriek beren hasierako gaitasunak galtzen dituzte denboraren poderioz, baita erabilpen baldintzen arabera ere. Horrek Li-ioizko baterietan oinarrituriko sistemen errentagarritasuna kolokan ezartzen du. Ondorioz, ... -
Development of a loop heat pipe 'LHP' thermal superconductor device with multicondensors
(2017-07-21)El mundo electrónico, en su avance en el incremento de integración ha llegado a un cuello de botella en su progresión en la miniaturización e integración. Este cuello de botella es la elevada densidad de flujo de calor ...