Search
Now showing items 121-130 of 137
Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)
(2021-05-21)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein isoform-1 [IL-22BPi1], -2 [IL-22BPi2], and -3 [IL-22BPi3]). Two of these, namely, IL-22BPi2 and IL-22BPi3, are capable of ...
Functional analysis of ankrd55, a multiple sclerosis risk gene with unknown function.
(2019-01-14)
El objetivo de este trabajo consiste en la caracterización de ANKRD55, un gen de función desconocida asociado a la esclerosis múltiple (EM). Para ello, por un lado, se realizó un análisis basado en DNA y expresión génica ...
Smooth muscle cell characterization and transcriptomic analysis in human carotid atherosclerotic plaques
(2018-10-19)
Las enfermedades cardiovasculares (CV) son una de las causas más importantes de discapacidad y muerte prematura en todo el mundo. Una de las causas subyacentes de las CV es la aterosclerosis. La aterosclerosis de carótida ...
Esklerosi anizkoitzaren IL22RA suszeptibilitate-genearen analisia
(2023-01-23)
Multiple sclerosis (MS) is a chronic inflammatory neurological disease whose underlying cause remains uncertain and can be influenced by different environmental and genetic factors. We have studied two MS-susceptibility ...
Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
(2023-01-20)
Several important cognitive functions affected by traumatic brain injury (TBI) depend on the hippocampus, which harnesses several forms of neural plasticity, among them adult neurogenesis, the generation of new neurons ...
Synaptic alterations in the hippocampus of an animal model of progressive parkinsonism and the effect of dopaminergic treatments
(2022-03-04)
This Ph.D. project is focused on the characterization of pathological events in the hippocampus, which could be related to non-motor manifestation in Parkinson's disease such as behavioral and memory impairments. For that ...
Mecanismos de regulación de la actividad del retrómero.
(2024-01-30)
Las células están constantemente moviendo material como parte de su inherente actividad e interacciones con el entorno. La red endosomal es un foco de redistribución de moléculas. Esta red recibe proteínas transmembrana, ...
Blocking ATP signaling and ROS generation preserves neurogenesis and network activity In epileptogenesis In hippocampal organotypic slice cultures.
(2024-01-26)
Epilepsy is a common neurological disorder, which lacks a comprehensive understanding of epileptogenesis. Temporal lobe epilepsy (TLE) in particular, often involves the hippocampus, with gliosis and abnormal neurogenesis. ...
Role of MCSF-activated microglia in amyloid-associated pathology
(2022-04-01)
Un evento clave que se desarrolla de forma temprana en la enfermedad de Alzheimer (EA) es el acúmulode las formas oligoméricas del péptido ß-amiloide (oAß) en el cerebro. En este estudio, hemosinvestigado el papel de la ...
Trastornos disautonómicos en la enfermedad de Parkinson
(2023-12-18)
La enfermedad de Parkinson es una enfermedad crónica neurodegenerativa sin tratamiento curativo en la actualidad. En ausencia de un tratamiento eficaz que frene, module o cure la enfermedad, el impacto en la calidad de ...