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Chemoenzymatic synthesis and immunological studies of Xylosylated N-glycans
(2016-06-07)
Glycosylation is one of the most common post-translational modifications in eukaryotic cells. It changes during cell development and differentiation and it is tissue and more importantly, species specific. While core ¿-1,6 ...
New challenges in the synthesis of non-isocyanate polyurethanes
(2018-12-18)
Entre todos los materiales plásticos, los poliuretanos (PU) representan el sexto polímero más utilizado en el mundo; se sintetizan industrialmente mediante la reacción entre un diol y un diisocianato, en presencia de un ...
Synthesis, applications and reactivity of 1,2,3-triazolium salts
(2015-07-10)
La tesis aborda los siguientes aspectos de la química de las sales de 3-alquil-1,2,3- triazolio:a) El estudio de nuevos alquinos catiónicos de 4-etinil-3-metil-1,2,3-triazolio como dipolarófilos en la reacción de cicloadición ...
Solid-phase synthesis of glicosaminoglycans
(2017-09-15)
Glycosaminoglycans (GAGs) are highly charged and linear polysaccharide repeating units (with the exception of keratin sulfate), which are further classified according their monosaccharide composition and glycosidic linkage. ...
Computational understanding of heterocyclisation reactions and synthesis of fluorinated isoquinolines
(2020-11-27)
The present thesis deals with three different topics that have in common the formation of carbo- and heterocycles. The whole work is organized as a synergy of experimental and computational studies to provide a deep ...
A computational glance at organometallic cyclizations and coupling reactions
(2016-07-18)
Organometallic chemistry is one of the main research topics in chemical science.Nowadays, organometallic reactions are the subject of intensive theoretical investigations.However, in many cases, only joint experimental and ...
1, 2, 3 - Triazoles as key frameworks in drug discovery & metal catalysis
(2017-07-07)
La tesis se enmarca dentro de la química de los 1H-1,2,3-triazoles y sus sales de N-alquil-triazolio. El trabajo realizado contempla los siguientes objetivos:1.- Sintetizar y estudiar los 1H-1,2,3-triazoles como plantillas ...
Novel studies on organocatalytic and stoichiometric C-C bond forming reactions
(2019-01-28)
Las diferentes generaciones de organocatalizadores basadas en prolinas no naturales han demostrado ser muy eficientes a la hora de catalizar reacciones de formación de enlaces carbono-carbono como la reacción aldólica y ...
Sustainable C–H Functionalization within Peptide & Heterocyclic Chemistry
(2020-11-10)
Chemistry is known to play a crucial role in the universal commitment to achieve sustainable methodologies in which the reduction of energy consumption and the production of waste constitute great challenges for the ...
Novel studies on enamine and acid organocatalysis on carbon-carbon bond forming reactions
(2016-03-11)
Los cicloaductos derivados de prolina no naturales densamente funcionalizados NO2-XL-OMe 5aa y NO2 NL-OMe 5aa poseen un gran interés en los campos de la química y biología ya que pueden complementar a los aminoácidos ...