Search
Now showing items 1-10 of 104
Modular magnetite-filled nanomicelles for multimodal imaging-guided development of effective anticancer vaccines
(2017-09-08)
Tanto las células cancerosas como muchos de los patógenos que causan enfermedades crónicas han desarrollado mecanismos para evadir al sistema inmune. Por lo tanto, es necesario desarrollar nuevas tecnologías que nos permitan ...
Transcriptional control of prostate cancer metabolism
(2017-12-18)
La transformación y la progresión tumoral van acompañados de cambios metabólicos. Los principales co-reguladores metabólicos son capaces de orquestar la modulación de múltiples rutas metabólicas a través de la regulación ...
Metabolic alterations in prostate cancer pathogenesis
(2016-09-16)
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs thatsustain cell growth, proliferation and promote cancer initiation and progression. In this thesis workwe describe a novel molecular mechanism ...
Physical principles underlying structure, mechanics and dynamic re-organization of hyaluronan-rich matrices - from tissues to supramolecular models in experiment and theory
(2016-07-29)
The goal of this research project is to understand the physical principles that underlie the structure, mechanics and dynamic reorganization of hyaluronan-rich pericellular and extracellular matrices. Many cells produce a ...
Structural basis of glycogen biosynthesis regulation in bacteria
(2017-09-26)
ADP-glucosa pirofosforilasa (AGPasa) es la enzyma responsable de la formación de ADP-glucosa, reacción limitante en la biosíntesis de glucógeno en bacterias y almidón en plantas, y su actividad se encuentra regulada ...
Identification of Tick Saliva Antigens as Vaccine Candidates and Immunotherapeutics
(2017-10-27)
Mice are widely used in research. This animal species has also beenextensively used to study the relationship between ticks and their mammalian hosts,including the design and test of vaccine candidates, although it is ...
Characterization of USP11 as a novel regulator of Hypoxia inducible factor a
(2019-11-27)
Adaptation to hypoxia is a puzzling and tightly regulated challenge. This adaptability involves a severe gene expression rewiring, which is mainly triggered by the Hypoxia Inducible transcription Factor (HIF). Canonically, ...
Molecular recognition between PCNA and proteins involved in DNA replication and repair: p15 and p12
(2019-12-19)
El antígeno nuclear de células en proliferación (PCNA) es un factor esencial en replicación y reparación de ADN en eucariotas. Forma un anillo homotrimérico que rodea y se desliza a lo largo del ADN, actuando como una ...
Structural study of CUG-repeating small RNAs complexed with silencing suppressor P19
(2014-02-24)
The study is focused on structural aspects of interaction between silencing suppressor p19 and CUG-repeating small RNAs. The work involves crystal structure determination of a protein-unbound RNA form and RNA fragments of ...
Design of protein-nanomaterial hybrids as tools for sensing, imaging and bioelectronics
(2022-06-17)
El diseño de proteínas permite construir herramientas nanotecnológicas adaptadas para su uso en campos como la biomedicina o la industria. Las proteínas de repetición CTPR son una buena opción para desarrollar nano-herramientas ...