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Structural study of CUG-repeating small RNAs complexed with silencing suppressor P19
(2014-02-24)
The study is focused on structural aspects of interaction between silencing suppressor p19 and CUG-repeating small RNAs. The work involves crystal structure determination of a protein-unbound RNA form and RNA fragments of ...
Molecular determinants of Kv7.2 surface expression
(2014-02-25)
El objetivo de esta tesis ha sido esclarecer las bases moleculares de la expresión en membrana de los canales M neuronales, crucial para una mejor comprensión de su funcionamiento. La densidad de canales en superficie se ...
Novel mechanisms for regulation of cell survival and migration by ceramide 1-phosphate
(2014-02-07)
Ceramide 1-phosphate is a bioactive sphingolipid that regulates important cell functions, including cell proliferation, apoptosis, migration or inflammation. Cell homeostasis is essential for the normal development of any ...
Delivery of small nucleic acids by conjugation to carbohydrates and lipids as novel research and therapeutic tools
(2014-03-12)
Small nucleic acids present a great potential to silence specific genes or inhibit the biological activity of specific proteins. Unfortunately, their poor cellular accessibility presents a big challenge for developing an ...