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Transcriptome regulation network in Multiple sclerosis: Role of circular RNAs.
(2021-02-09)
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, that leads to neurological disability. The disease course and clinical phenotype are highly variable and therefore, biomarkers that can ...
Ultrastructural and physiological studies on the cannabinoid CB1 receptor localized in astroglia.
(2021-10-28)
The cannabinoid CB1 receptor-mediated functions in astrocytes are highly dependent on the CB1 receptor
distribution in these glial cells relative to neuronal sites, particularly at the nearby synapses under normal
or ...
Atxikimendua eta Aurpegi-Emozioen Antzematea Mugako Nortasunaren Nahasmendua duten Pazienteetan
(2021-04-30)
Mugako Nortasunaren Nahasmendua (MNN) atxikimenduaren zailtasunekin lotu izan da, helduaroan bereziki atxikimendu-antsietate maila altuarekin. Bestalde, MNN-n Aurpegi-Emozioen Antzematea (AEA) aztertu dituzten ikerketetan ...
Glial localization of the cannabinoid CB1 and CB2 receptors in a mouse model of Alzeimer's disease
(2021-10-29)
Alzheimer gaixotasuna adinekoen artean eman ohi den gaixotasun endekapenezko ohikoena da, baita dementzia motarik sarriena ere, kognizio eta oroimen asaldurak sortzen dituena. Oraingoz ez da lortu gaixotasun horren patogenesia ...
Characterization and pharmacological modulation of calcium handling proteins in Limb-Girdle Muscle Dystrophy type R1
(2021-01-27)
Limb-girdle muscle dystrophy type R1 (LGMDR1) is the most common form of limb-girdle muscle dystrophy, currently with no effective treatment. LGMDR1 is caused by mutations in the CAPN3 gene and is characterized by reduced ...
Microglial phagocytosis form development to neurodegenerative diseases
(2021-09-30)
a microglía es el macrófago residente del sistema nervioso central (SNC). Estos centinelas cerebrales "escanean" continuamente el parénquima cerebral con sus procesos delgados, largos y ramificados que ayudan a mantener ...
Synaptic dysfunction in Parkinson's Disease: functional and ultrastructural study of the striatal synapses in an animal model of progressive parkinsonism
(2021-02-26)
This Ph.D. project involves the temporal sequence of the earliest functional and structural events in the striatal synapses in a rat model of progressive parkinsonism induced by overexpression of human ¿-synuclein (h¿-syn) ...
Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)
(2021-05-21)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein isoform-1 [IL-22BPi1], -2 [IL-22BPi2], and -3 [IL-22BPi3]). Two of these, namely, IL-22BPi2 and IL-22BPi3, are capable of ...