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Design and engineering of artificial metabolic cells for chemical manufacturing.
(2019-04-09)
La biocatálisis industrial ha demostrado ser una alternativa más económica y limpia a la síntesis químicatradicional. Sin embargo, la baja estabilidad de las enzimas, el insuficiente reciclaje de moléculas y laslimitaciones ...
Una nueva aproximación a la síntesis de heterociclos pirrolofusionados basada en la reacción de amidación de alquinos asistida por el reactivo de yodo hipervalente PIFA
(2014-02-05)
En la presente memoria se describe el trabajo de investigación llevado a cabo en relación al desarrollo de nuevas aplicaciones sintéticas de la reacción de heterociclación de alquinos funcionalizados mediante el empleo del ...
NMR studies of the interactions of glycan antigens with monoclonal antibodies.
(2020-06-29)
Carbohydrates are one of the most variable and complex molecules of biological systems. They are usually located at the cell membrane, mainly as glycoconjugates, glycoproteins or glycolipids and play an important role in ...
Ultrasmall Glyco-Gold Nanoparticles: Synthesis Optimization, Characterization and Applications in Immune-Cell Targeting
(2020-09-16)
Gold nanoparticles (GNP) are hybrid materials, with excellent physicochemical characteristics, made of a gold core and a corona of organic molecules, amongst them carbohydrates. Ultrasmall GNP (nanoclusters) are usually ...
NMR and molecular recognition of compounds related to the immune system.
(2019-03-25)
Glycans are among the most varied and complex molecules in biological systems. The glycosylation process is the most complex and widespread modification of proteins and lipids, with an unsurpassed capacity to generate a ...
Activación de aldehídos a,b-insaturados mediante aminocatálisis en procesos enantioselectivos. Cicloadiciones (3+2) y reacciones en cascada Michael/Henry
(2014-01-21)
During the research that it is summarized in the present memory, the activation of enals via iminium ion catalysis in different transformations has been studied.
Firstly, a 1,3-dipolar cycloaddition between stable azomethine ...
Michael initiated organocatalytic cascade reactions
(2016-07-20)
The methodologies based on Michael initiated cascade reactions represent avery useful synthetic strategy for the formation of complex compounds, startingfrom simple substrates and using straightforward procedures. In this ...
Lithium and Palladium mediated cyclization reactions towards the stereocontrolled synthesis of (hetero)benzo-fused indolizidines
(2016-03-18)
The research work described in this thesis is focused on the use of lithium and palladium mediated cyclization reactions for the stereocontrolled synthesis of (hetero)benzo-fused indolizidines through carbon-carbon bond ...
Transition metal-catalyzed reactions. Cascade reactions and chiral ligand synthesis
(2020-05-15)
El trabajo de investigación que se recoge en la presente memoria se centra, por una parte, en el desarrollo de nuevos métodos sintéticos basados en el empleo de reacciones tipo Heck catalizadas por Pd(0) para la formación ...
Organocatalytic and enantioselective transannular reactions: novel strategies for the asymmetric synthesis of polycyclic structures.
(2019-06-25)
Las reacciones transanulares son procesos con un gran potencial sintético ya que permiten acceder a estructuras policíclicas de forma sencilla y con un alto grado de economía de átomos. Por definición, una reacción ...