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Activity of carvacrol, cinnamaldehyde, citral and thymol, and their monoolein-based liposomes against oral biofilm-producing Candida isolates
(2021-11-05)
Las candidiasis orales son infecciones fúngicas comunes, causadas principalmente por Candida albicans. Sin embargo, actualmente otras especies de Candida menos sensibles a los fármacos antifúngicos han aumentado su ...
Micro and Macro-Evolutionary Studies in Non-Model Species: a Transcriptomic Perspective in Teleosts
(2021-12-21)
Los recursos genómicos y las herramientas bioinformáticas son muy escasas en especies no modelo. ElRNA-Seq puede ser una herramienta efectiva para generar tales recursos genómicos con el objetivo derevelar la variación ...
Arming NK cells with chimeric antigen receptors (CARs) for treatment of refractory and/or relapsed hematological cancers: preclinical study to determine the best cell source.
(2020-02-10)
Acute Lymphoblastic Leukemia (ALL) and Chronic Lymphocytic Leukemia (CLL) are the most prevalent hematological cancers in children and elder patients respectively. Sometimes, standard treatments are not enough for curing ...
Optimizing pharmacotherapy in the elderly using modelling and simulation methods. Application to Bilastine
(2021-11-29)
This research project was designed to acquire a deeper knowledge on how physiological changes during aging mayaffect the pharmacokinetics (PK) and pharmacodynamics (PD). Elderly adults are a vulnerable population due to ...
Biomolecular Characterization of PCNA interacting proteins.
(2020-07-27)
PCNA (Proliferating Cellular Nuclear Antigen) es la abrazadera que es desliza sobre el ADN necesaria para la replicación del ADN y la respuesta al daño. PCNA interactúa con numerosas proteínas a través de una secuencia ...
Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)
(2021-05-21)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein isoform-1 [IL-22BPi1], -2 [IL-22BPi2], and -3 [IL-22BPi3]). Two of these, namely, IL-22BPi2 and IL-22BPi3, are capable of ...
Mechanism for ESCPE-1 mediated membrane remodelling and cargo selection in endosomal
(2020-10-02)
El reciclaje de proteínas es fundamental para mantener la homeostasis celular. Este trabajo se enfoca en el reciclaje de proteínas que llegan a los endosomas. Allí, las proteínas transmembrana (receptores) son recicladas ...