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Biofunctional iron oxide nanoparticles as vaccine adjuvants for enhanced anti-cancer immunotherapy
(2017-12-15)
En esta tesis se aborda el diseño y caracterización de una vacuna basada en nanoparticulas de óxido de hierro para su aplicación en inmunoterapia del cáncer. Concretamente, las nanoparticulas están biofuncionalizadas con ...
New neuroimaging methods for clinical neuroscience and neurological disorders
(2015-10-27)
Clinical neuroscience today makes use of state-of-the-art neuroimaging to study structural and functional brain data to improve diagnosis and prognosis in different neurological disorders.In this thesis dissertation, I ...
Lipidomics in melanoma: identification of new lipid prognostic biomarkers
(2020-06-16)
El objetivo de esta tesis doctoral fue el de encontrar nuevos biomarcadores para el melanoma, ya que lasupervivencia de los pacientes se reduce dramáticamente cuando no se detecta en la fase temprana de laenfermedad. Para ...
Study of the distribution of nuclear basket-related nucleoporins after histone deacetylase inhibition.
(2021-07-14)
El complejo del poro nuclear está constituido por proteínas denominadas nucleoporinas cuya función erasupuestamente restringida al transporte nucleocitoplasmático. Evidencias recientes, sugieren que lasnucleoporinas ...
DLK1 and DLK2 characterization in mouse salivary gland development
(2015-12-11)
Organogenesia seinalizazio bide ezberdinez gidatutako prozesu konplexua da. Askotan organu ezberdinen garapena seinalizazio faktore berdinez dago erregulatuta. Gainera, seinalizazio bideen ikerketa garapena ezagutarazteko ...
Neuroprotective effects of resveratrol and docosahexaenoic acid antioxidants in perinatal hypoxic-ischemic brain injury in rats
(2015-12-11)
Umeen erikortasun eta hilkortasunaren kausa nagusienetariko bat hipoxia-iskemia perinatala da, hortazbere aurkako estrategia neurobabesle berri eta eraginkorragoak aurkitzearen premia. Zentzu honetanerresberatrola eta azido ...
Computational predictive modeling of integrated cerebral metabolism, electrophysiology and hemodynamics.
(2019-02-12)
Understanding the energetic requirement of brain cells during resting state and during high neural activity is a very active research area where mathematical models have contributed significantly by providing a context for ...
Birsortze neuralean erabiltzeko hortz muineko ama zelulen gaitasun funtzionalaren azterketa
(2018-12-19)
Ezaguna da hortz muin helduak zelula ama populazio garrantzitsu bat duela barnean, hauei, hortz muineko zelula amak deritze (ingelesez, dental pulp stem cells, DPSCs). Oinarrizko egoeran aurkezten dituzten zelula neuralen ...
Advances of high-order interactions in the human brain: Applications in aging and neurodegeneration.
(2022-10-05)
The human brain generates a large repertoire of spatio-temporal patterns, which supporta wide variety of motor, cognitive, and behavioral functions. The most acceptedhypothesis in modern neuroscience is that each of these ...
Role of notch and wnt signaling in metabolic and epigenetic reprogramming of human dental pulp stem cells (DPSCs)
(2019-03-01)
Las Células Stem de Pulpa Dental (DPSCs; en inglés) son células madre extraídas de la pulpa dental de terceros molares de pacientes. Presentan unas propiedades que las convierte en un recurso especialmente interesante para ...