BackBrowsing Artículos, Comunicaciones, Libros by Author "Maestro Burzaco, Aitor"
Now showing items 1-6 of 6
-
A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents
; López Francés, Adrián
; ; ; ; Martínez de Marigorta Izaga, Edorta ; Pedraz Muñoz, José Luis ; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2021-08-09)
An efficient synthetic methodology for the preparation of 3-amino 1,5-dihydro-2H-pyrrol-2-ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is reported. In addition, the densely substituted ... -
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
Maestro Burzaco, Aitor; ; López Francés, Adrián; Martínez de Marigorta Izaga, Edorta ; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2021-05-27)
Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the ... -
Diethyl(benzamido(diisopropoxyphosphoryl)methyl) phosphonate
López Francés, Adrián; Palacios Gambra, Francisco Javier ; ; Vicario Hernando, Javier (MDPI, 2022-08-11)
Bisphosphonates are widely used in medicine and related areas, mainly for the treatment of bone diseases, such as osteoporosis. However, their synthesis is usually performed under harsh reaction conditions. In order to ... -
Phosphine-catalysed transformations of ortho- and para-quinone methides
(RSC, 2023)Organocatalytic methodologies for the derivatization of o-QM, p-QM and the analogous aza-QM have been recently developed and involve different catalytic systems such as phosphoric acids, thioureas, squaramides, NHC carbenes ... -
Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives
; ; Alonso Pérez, Concepción Estibaliz; Martínez de Marigorta Izaga, Edorta ; Rubiales Alcaine, María Gloria ; Vicario Hernando, Javier ; Palacios Gambra, Francisco Javier (Elsevier, 2018-09-15)
An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. ... -
Synthesis of Tetrasubstituted Phosphorus Analogs of Aspartic Acid as Antiproliferative Agents
; ; López Francés, Adrián; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2022-11-18)
An efficient general method for the synthesis of a wide family of α-aminophosphonate analogs of aspartic acid bearing tetrasubstituted carbons is reported through an aza-Reformatsky reaction of α-iminophosphonates, generated ...