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Development and Maintenance of the Brain’s Immune Toolkit: Microglia and Non-Parenchymal Brain Macrophages
(Wiley, 2018-06)
Microglia and non-parenchymal macrophages located in the perivascular space, the meninges and the choroid plexus are independent immune populations that play vital roles in brain development, homeostasis, and tissue healing. ...
The C Terminus of the Ribosomal-Associated Protein LrtA Is an Intrinsically Disordered Oligomer
(MDPI, 2018-12-05)
The 191-residue-long LrtA protein of Synechocystis sp. PCC 6803 is involved in post-stress survival and in stabilizing 70S ribosomal particles. It belongs to the hibernating promoting factor (HPF) family, intervening in ...
Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice
(MDPI, 2018-10)
Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice. ...
Quantum cosmology of the Big Rip: Within GR and in a modified theory of gravity
(MDPI, 2017-04-14)
Quantum gravity is the theory that is expected to successfully describe systems that are under strong gravitational effects while at the same time being of an extreme quantum nature. When this principle is applied to the ...
D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
(Nature Publishing, 2018-06-11)
Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement ...
In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets
(MDPI, 2018-02-05)
Monocytes are bone marrow-derived leukocytes that are part of the innate immune system. Monocytes are divided into three subsets: classical, intermediate and non-classical, which can be differentiated by their expression ...
Promotion of self-nucleation with latent Form I nuclei in polybutene-1 and its copolymer
(American Chemical Society, 2018-08-02)
The formation of Form I nuclei of polybutene-1 (PB-1) and its copolymer with polyethylene (PB1-ran-PE) has been studied by means of modified self-nucleation protocols. Even when the self-nucleation temperature was high ...
Regulation of Nociceptive Plasticity Threshold and DARPP-32 Phosphorylation in Spinal Dorsal Horn Neurons by Convergent Dopamine and Glutamate Inputs
(Public Library Science, 2016-09-09)
Dopamine can influence NMDA receptor function and regulate glutamate-triggered long-term changes in synaptic strength in several regions of the CNS. In spinal cord, regulation of the threshold of synaptic plasticity may ...
Influence of chain topology (cyclic versus linear) on the nucleation and isothermal crystallization of poly(L-lactide) and poly(D-lactide)
(American Chemical Society, 2018-02-20)
In this paper, ring closure click chemistry methods have been used to produce cyclic c-PLLA and c-PDLA of a number average molecular weight close to 10 kg/mol. The effects of stereochemistry of the polymer chains and their ...
Crystallization of isodimorphic aliphatic random copolyesters: pseudo-eutectic behavior and double-crystalline materials
(Elservier, 2018-02-28)
Isodimorphic random copolyesters are intriguing polymeric materials that can crystallize in their entire composition range, despite the random distribution of comonomer units along their chains. This behavior stems from ...