Browsing ACHUCARRO by Title
Now showing items 10-29 of 33
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Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine
(Public Library Science, 2014-03-05)Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ... -
Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
(Biomed Central, 2017-07-24)Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ... -
From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia
(Frontiers Research Foundation, 2015-04-14)Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ... -
FTY720 attenuates excitotoxicity and neuroinflammation
(BioMed Central, 2015-05-08)Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ... -
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
(2018-05-04)The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ... -
Interacción entre quinasas y moléculas apoptóticas en la muerte oligodendroglial excitotóxica
(2016-05-27)El fenómeno de excitotoxicidad glutamatérgica supone una de las causas subyacentes de multitud de enfermedades neurodegenerativas y afecta, entre otros tipos celulares, a los oligodendrocitos. Precisamente la vulnerabilidad ... -
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
(Frontiers Research Foundation, 2013-01)Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ... -
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
(2016)Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ... -
Neurotransmitter signaling in the pathophysiology of microglia
(Frontiers Research Foundation, 2013)Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ... -
Never-resting microglia: physiological roles in the healthy brain and pathological implications
(Frontiers Research Foundation, 2014-08-15)Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ... -
NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation
(Frontiers Research Foundation, 2013-12-18)Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ... -
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
(Nature Publishing Group, 2012-02)We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ... -
Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
(Hindawi, 2016)Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ... -
Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
(null, 2016)Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ... -
Papel de las GTPasas de la familia rho en la señalización mediada por el receptor P2X7
(2013-09-24)El objetivo de este proyecto es estudiar la señalización del receptor P2X7 en respuesta a ATP en macrófagos J774A.1 y en células CHO K1. Para ello, se subclonó el gen que codifica para la proteína P2X7 en el vector PMT2 ... -
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Pio del Rio Hortega and the discovery of the oligodendrocytes
(Frontiers Research Foundation, 2015-07-07)Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ... -
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
(BioMed Central, 2013)Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain ... -
Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation
(null, 2015)Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 ... -
Regulación de las GTPasas de la familia Ras y la viabilidad de neuronas dopaminérgicas en respuesta a la señalización purinérgica
(2015-07-27)El ATP es una molécula natural cuya liberación descontrolada puede elevar su concentración extracelular a rango mM y promover la estimulación de receptores purinérgicos. Se sabe que esta estimulación tiene efectos citotóxicos ...