Now showing items 1-20 of 33

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      1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

      Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier ORCID; Apraiz, A.; Arrizabalaga Uriarte, Oskar ORCID; Vellon, L.; Alberdi Alfonso, Elena María ORCID; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis ORCID (Nature Publishing Group, 2013-01)
      1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
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      A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling 

      Quintela López, Tania; Ortiz Sanz, Carolina; Serrano Regal, María Paz; Gaminde Blasco, Adhara Mikaela; Valero Gómez-Lobo, Jorge; Baleriola, Jimena; Sánchez Gómez, María Victoria ORCID; Matute Almau, Carlos José; Alberdi Alfonso, Elena María ORCID (Nature Publishing Group, 2019-06-06)
      Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ...
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      A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation 

      Cela López, José M.; Camacho Roldán, Claudio J.; Gómez Lizarraga, Gorka; Martínez, Vicente (MDPI, 2021-07-28)
      Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and ...
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      Arquitectura subcelular del sistema endocannabinoide en el núcleo ventromedial del hipotálamo de ratón 

      Reguero Acebal, Leire ORCID (2014-01-30)
      El sistema endocannabinoide (eCB) es un complejo sistema endógeno de señalización, que participa en la modulación de la transmisión sináptica en múltiples circuitos cerebrales, incluyendo los que regulan el apetito, ingesta ...
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      ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP 

      Burzaco Galán, Jaione; Conde Fernández, Manuel; Parada, Luis A.; Zugaza Gurruchaga, José Luis ORCID; Dehaye, Jean-Paul; Marino Sánchez, Aida Luisa ORCID (Public Library of Science, 2013)
      In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ...
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      Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease 

      Alberdi Alfonso, Elena María ORCID; Wyssenbach Ibarra, Ane; Alberdi, María; Sánchez Gómez, María Victoria ORCID; Cavaliere, Fabio; Rodríguez, José J.; Verkhratsky, Alexei; Matute Almau, Carlos José (2013)
      Neurotoxic effects of amyloid β peptides are mediated through deregulation of intracellular Ca2+ homeostasis and signaling, but relatively little is known about amyloid β modulation of Ca2+ homeostasis and its pathological ...
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      CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels 

      Ruiz Núñez, Asier ORCID; Alberdi Alfonso, Elena María ORCID; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)
      Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...
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      Combined Fluorescent-Chromogenic In Situ Hybridization for Identification and Laser Microdissection of Interphase Chromosomes 

      Paz Gandiaga, Nerea; Zabala, Amaia; Royo, Félix; García-Orad Carles, África; Zugaza Gurruchaga, José Luis ORCID; Parada, Luis A. (Public Library of Science, 2013)
      Chromosome territories constitute the most conspicuous feature of nuclear architecture, and they exhibit non-random distribution patterns in the interphase nucleus. We observed that in cell nuclei from humans with Down ...
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      Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis 

      Lutz, Sarah E.; González Fernández, Estibaliz; Chara Ventura, Juan Carlos; Pérez Samartín, Alberto Luis ORCID; Tarassishin, Leonid; Negoro, Hiromitsu; Patel, Naman K.; Suadicani, Sylvia O.; Lee, Sunhee C.; Matute Almau, Carlos José; Scemes, Eliana (Public Library of Science, 2013-06)
      Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. ...
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      Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine 

      Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria ORCID; Domercq García, María ORCID; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
      Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
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      Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury 

      Cipriani, Raffaela ORCID; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; Matute Almau, Carlos José (Biomed Central, 2017-07-24)
      Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ...
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      From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia 

      Tremblay, Marie-Ève; Lecours, Cynthia; Samson, Louis; Sánchez Zafra, Víctor; Sierra Saavedra, Amanda (Frontiers Research Foundation, 2015-04-14)
      Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ...
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      FTY720 attenuates excitotoxicity and neuroinflammation 

      Cipriani, Raffaela ORCID; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; Matute Almau, Carlos José (BioMed Central, 2015-05-08)
      Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...
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      Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling 

      Martín Muñoz, Abraham; Domercq García, María ORCID; Matute Almau, Carlos José (2018-05-04)
      The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ...
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      Interacción entre quinasas y moléculas apoptóticas en la muerte oligodendroglial excitotóxica 

      Canedo Antelo, Manuel (2016-05-27)
      El fenómeno de excitotoxicidad glutamatérgica supone una de las causas subyacentes de multitud de enfermedades neurodegenerativas y afecta, entre otros tipos celulares, a los oligodendrocitos. Precisamente la vulnerabilidad ...
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      Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis 

      Sierra Saavedra, Amanda; Abiega Etxabe, Oihane; Shahraz, Anahita; Neumann, Harald (Frontiers Research Foundation, 2013-01)
      Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ...
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      Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling 

      Abiega Etxabe, Oihane; Beccari Galeano, Marlene Soledad; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq García, María ORCID; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris Guerrero, Ignacio; Valero Gómez-Lobo, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco Ruiz, María del Mar; Matute Almau, Carlos José; Maletic-Savatic, Mirjana; Encinas Pérez, Juan Manuel; Sierra Saavedra, Amanda (2016)
      Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ...
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      Neurotransmitter signaling in the pathophysiology of microglia 

      Domercq García, María ORCID; Vázquez Villoldo, Nuria; Matute Almau, Carlos José (Frontiers Research Foundation, 2013)
      Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
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      Never-resting microglia: physiological roles in the healthy brain and pathological implications 

      Sierra Saavedra, Amanda; Tremblay, Marie-Ève; Wake, Hiroaki (Frontiers Research Foundation, 2014-08-15)
      Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ...
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      NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation 

      Cavaliere, Fabio; Benito Muñoz, Mónica; Panicker, Mitradas; Matute Almau, Carlos José (Frontiers Research Foundation, 2013-12-18)
      Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ...