Now showing items 1-20 of 28

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      1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

      Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier; Apraiz, A.; Arrizabalaga, O.; Vellon, L.; Alberdi Alfonso, Elena María; Cavaliere, Fabio; Lacerda, H. M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
      1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
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      Arquitectura subcelular del sistema endocannabinoide en el núcleo ventromedial del hipotálamo de ratón 

      Reguero Acebal, Leire (2014-01-30)
      El sistema endocannabinoide (eCB) es un complejo sistema endógeno de señalización, que participa en la modulación de la transmisión sináptica en múltiples circuitos cerebrales, incluyendo los que regulan el apetito, ingesta ...
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      ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP 

      Burzaco Galán, Jaione; Conde Fernández, Manuel; Parada, Luis A.; Zugaza Gurruchaga, José Luis; Dehaye, Jean-Paul; Marino Sánchez, Aida Luisa (Public Library of Science, 2013)
      In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ...
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      Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease 

      Alberdi Alfonso, Elena María; Wyssenbach, Ane; Alberdi, María; Sánchez-Gómez, Mª V.; Cavaliere, Fabio; Rodríguez, José J.; Verkhratsky, Alexei; Matute Almau, Carlos José (2013)
      Neurotoxic effects of amyloid β peptides are mediated through deregulation of intracellular Ca2+ homeostasis and signaling, but relatively little is known about amyloid β modulation of Ca2+ homeostasis and its pathological ...
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      CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels 

      Ruiz Núñez, Asier; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)
      Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...
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      Combined Fluorescent-Chromogenic In Situ Hybridization for Identification and Laser Microdissection of Interphase Chromosomes 

      Paz Gandiaga, Nerea; Zabala, Amaia; Royo, Félix; García-Orad Carles, África; Zugaza Gurruchaga, José Luis; Parada, Luis A. (Public Library of Science, 2013)
      Chromosome territories constitute the most conspicuous feature of nuclear architecture, and they exhibit non-random distribution patterns in the interphase nucleus. We observed that in cell nuclei from humans with Down ...
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      Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis 

      Lutz, Sarah E.; González Fernández, Estibaliz; Chara Ventura, Juan Carlos; Pérez Samartín, Alberto Luis; Tarassishin, Leonid; Negoro, Hiromitsu; Patel, Naman K.; Suadicani, Sylvia O.; Lee, Sunhee C.; Matute Almau, Carlos José; Scemes, Eliana (Public Library of Science, 2013-06)
      Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. ...
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      Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine 

      Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria; Domercq García, María; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
      Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
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      From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia 

      Tremblay, Marie-Ève; Lecours, Cynthia; Samson, Louis; Sánchez Zafra, Víctor; Sierra Saavedra, Amanda (Frontiers Research Foundation, 2015-04-14)
      Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ...
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      FTY720 attenuates excitotoxicity and neuroinflammation 

      Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez Antigüedad, Alfredo; Matute Almau, Carlos José (BioMed Central, 2015-05-08)
      Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...
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      Increased neuronal death and disturbed axonal growth in the Polμ-deficient mouse embryonic retina 

      Baleriola, Jimena; Álvarez-Lindo, Noemí; Villa, Pedro de la; Bernad, Antonio; Blanco, Luis; Suárez, Teresa; Rosa, Enrique J. de la (, 2016)
      Programmed cell death occurs naturally at different stages of neural development, including neurogenesis. The functional role of this early phase of neural cell death, which affects recently differentiated neurons among ...
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      Interacción entre quinasas y moléculas apoptóticas en la muerte oligodendroglial excitotóxica 

      Canedo Antelo, Manuel (2016-05-27)
      El fenómeno de excitotoxicidad glutamatérgica supone una de las causas subyacentes de multitud de enfermedades neurodegenerativas y afecta, entre otros tipos celulares, a los oligodendrocitos. Precisamente la vulnerabilidad ...
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      Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis 

      Sierra Saavedra, Amanda; Abiega Etxabe, Oihane; Shahraz, Anahita; Neumann, Harald (Frontiers Research Foundation, 2013-01)
      Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ...
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      Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling 

      Abiega, Oihane; Beccari, Sol; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq García, María; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris, Iñaki; Valero, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco, Maria dM; Matute Almau, Carlos José; Maletic-Savatic, Mirjana; Encinas Pérez, Juan Manuel; Sierra Saavedra, Amanda (2016)
      Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ...
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      Neurotransmitter signaling in the pathophysiology of microglia 

      Domercq García, María; Vázquez Villoldo, Nuria; Matute Almau, Carlos José (Frontiers Research Foundation, 2013)
      Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
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      Never-resting microglia: physiological roles in the healthy brain and pathological implications 

      Sierra Saavedra, Amanda; Tremblay, Marie Eve; Wake, Hiroaki (Frontiers Research Foundation, 2014-08-15)
      Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ...
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      NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation 

      Cavaliere, Fabio; Benito Muñoz, Mónica; Panicker, Mitradas; Matute Almau, Carlos José (Frontiers Research Foundation, 2013-12-18)
      Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ...
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      Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate 

      Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2012-02)
      We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ...
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      Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders 

      Cavaliere, Fabio; Benito-Muñoz, Monica; Matute Almau, Carlos José (null, 2016)
      Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ...
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      Papel de las GTPasas de la familia rho en la señalización mediada por el receptor P2X7 

      Iturrioz Rodríguez, Nerea (2013-09-24)
      El objetivo de este proyecto es estudiar la señalización del receptor P2X7 en respuesta a ATP en macrófagos J774A.1 y en células CHO K1. Para ello, se subclonó el gen que codifica para la proteína P2X7 en el vector PMT2 ...