Show simple item record

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

dc.contributor.authorAbiega Etxabe, Oihanees
dc.contributor.authorBeccari Galeano, Marlene Soledades
dc.contributor.authorDiaz-Aparicio, Irunees
dc.contributor.authorNadjar, Agneses
dc.contributor.authorLayé, Sophiees
dc.contributor.authorLeyrolle, Quentines
dc.contributor.authorGómez-Nicola, Diegoes
dc.contributor.authorDomercq García, María ORCIDes
dc.contributor.authorPérez-Samartín, Albertoes
dc.contributor.authorSánchez-Zafra, Víctores
dc.contributor.authorParis Guerrero, Ignacioes
dc.contributor.authorValero Gómez-Lobo, Jorgees
dc.contributor.authorSavage, Julie C.es
dc.contributor.authorHui, Chin-Waies
dc.contributor.authorTremblay, Marie-Èvees
dc.contributor.authorDeudero, Juan J. P.es
dc.contributor.authorBrewster, Amy L.es
dc.contributor.authorAnderson, Anne E.es
dc.contributor.authorZaldumbide Dueñas, Lauraes
dc.contributor.authorGalbarriatu, Laraes
dc.contributor.authorMarinas, Ainhoaes
dc.contributor.authorVivanco Ruiz, María del Mares
dc.contributor.authorMatute Almau, Carlos Josées
dc.contributor.authorMaletic-Savatic, Mirjanaes
dc.contributor.authorEncinas Pérez, Juan Manueles
dc.contributor.authorSierra Saavedra, Amandaes
dc.date.accessioned2016-11-28T08:29:22Z
dc.date.available2016-11-28T08:29:22Z
dc.date.issued2016es
dc.identifier.citationPLOS Biology 14(5) : (2016) // e1002466es
dc.identifier.issn1545-7885es
dc.identifier.urihttp://hdl.handle.net/10810/19619
dc.description.abstractPhagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and inflammation.es
dc.language.isoenges
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectmedicinees
dc.subjectneurosciencees
dc.subjectneurobiologyes
dc.titleNeuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
dc.typeinfo:eu-repo/semantics/articlees
dc.relation.publisherversionhttp://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002466es
dc.identifier.doi10.1371/journal.pbio.1002466es
dc.subject.categoriaAGRICULTURAL AND BIOLOGICAL SCIENCES
dc.subject.categoriaBIOCHEMISTRY AND MOLECULAR BIOLOGY
dc.subject.categoriaIMMUNOLOGY AND MICROBIOLOGY
dc.subject.categoriaNEUROSCIENCES


Files in this item

Thumbnail
Name:
RVRBWDJV.pdf
Size:
27.23Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record