Revealing the molecular mechanism underlying inhibition of FAPs adipogenesis in co-culture with myotubes

Abstract

[EN] The characterization of the molecular mechanisms that control fibro-adipogenic progenitors (FAPs) differentiation into adipocytes when they are co-cultured with myotubes. FAPs are known to have a dual role in skeletal muscle; on one hand, in healthy conditions, they promote its regenerations, while in pathological conditions they contribute to fatty and fibrous tissue filtration. The molecular mechanism that controls their differentiation into adipocytes is not fully characterized, but cell-cell contact with myotubes seems to play an important role. In this project I tried to characterize the molecular mechanism underlying the inhibition of the adipogenic differentiation.