Revisión del proceso diagnóstico clínico-patológico en linfomas cutáneos B y T: experiencia en el HUA

Abstract

[EN] Background. The involvement of the skin in neoplastic lymphoproliferative disorders can occur either by an affectation secondary to a systemic neoplasm or by a primary affectation of the skin, which is considered a primary cutaneous lymphoma, a nonHodgkin lymphoma presenting in the skin with no evidence of extracutaneous disease at the time of diagnosis. Clinical and histological diagnosis of cutaneous lymphoproliferative disorders is a challenge in dermatopathology. Objective. The aim of this paper is to review a selection of cases of cutaneous lymphoma occurred during the past three years in the Hospital Universitario Araba (HUA), focusing on the clinical and pathological diagnostic workup as a whole, to try to meet the difficulties encountered and compare them with those found in the medical literature and highlight the importance of clinical and histological correlation. Methods. Four cases occurred in the HUA during 2015-2018 were selected and compared through a systematic review of cutaneous lymphoma diagnostic workup in articles published in online medical databases and journals. Results. Each case is exposed and analyzed, emphasizing the time elapsed from the first consultation of the patient to final diagnosis, the number of biopsies that each case required, the inquiries made to external centers to confirm the diagnoses and the intervention of different departments. The information found during the bibliographic review of each case is exposed. Conclusion. Clinical and pathological correlation is crucial and should be materialized in the development of sessions and the organization of interdisciplinary committees, in which the diagnosis of cutaneous lymphoma is addressed jointly by the departments involved.