Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
dc.contributor.author | Santaolalla Sanchez, Francisco Javier | |
dc.contributor.author | Gutierrez Posso, Juan David | |
dc.contributor.author | Santaolalla Montoya, Francisco | |
dc.contributor.author | Zabala López de Maturana, Javier Aitor | |
dc.contributor.author | Arrizabalaga Iriondo, Ane | |
dc.contributor.author | Revuelta Aramberri, Miren | |
dc.contributor.author | Sánchez del Rey, Ana Salomé | |
dc.date.accessioned | 2024-10-02T12:25:59Z | |
dc.date.available | 2024-10-02T12:25:59Z | |
dc.date.issued | 2024-09-12 | |
dc.identifier.citation | Antioxidants 13(9) : (2024) // Article ID 1105 | es_ES |
dc.identifier.issn | 2076-3921 | |
dc.identifier.uri | http://hdl.handle.net/10810/69622 | |
dc.description.abstract | Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration of sound exposure. NIHL leads to the production of a reactive oxygen (ROS) inflammatory response and the activation of apoptotic pathways, DNA fragmentation, and cell death. In this situation, antioxidants can interact with free radicals as well as anti-apoptotics or anti-inflammatory substances and stop the reaction before vital molecules are damaged. Therefore, the aim of this study was to analyze the effects of different pharmacological treatments, focusing on exogenous antioxidants, anti-inflammatories, and anti-apoptotics to reduce the cellular damage caused by acoustic trauma in the inner ear. Experimental animal studies using these molecules have shown that they protect hair cells and reduce hearing loss due to acoustic trauma. However, there is a need for more conclusive evidence demonstrating the protective effects of antioxidant/anti-inflammatory or anti-apoptotic drugs’ administration, the timeline in which they exert their pharmacological action, and the dose in which they should be used in order to consider them as therapeutic drugs. Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat noise-induced hearing loss. | es_ES |
dc.description.sponsorship | The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The work was financed by IIS Biobizkaia and the University of the Basque Country UPV/EHU (GIU22-015). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | |
dc.subject | inner ear | es_ES |
dc.subject | noise-induced hearing loss | es_ES |
dc.subject | noise exposure | es_ES |
dc.subject | acoustic trauma | es_ES |
dc.subject | reactive oxygen species | es_ES |
dc.subject | antioxidants | es_ES |
dc.subject | inflammation | es_ES |
dc.subject | anti-apoptotic drugs | es_ES |
dc.subject | anti-inflammatory treatment | es_ES |
dc.title | Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2024-09-27T13:19:35Z | |
dc.rights.holder | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2076-3921/13/9/1105 | es_ES |
dc.identifier.doi | 10.3390/antiox13091105 | |
dc.departamentoes | Dermatología, oftalmología y otorrinolaringología | |
dc.departamentoes | Fisiología | |
dc.departamentoeu | Fisiologia | |
dc.departamentoeu | Dermatologia, oftalmologia eta otorrinolaringologia |
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Except where otherwise noted, this item's license is described as © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).