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MGRN1 as a Phenotypic Determinant of Human Melanoma Cells and a Potential Biomarker
(MDPI, 2022-07-26)
Mahogunin Ring Finger 1 (MGRN1), a ubiquitin ligase expressed in melanocytes, interacts with the α melanocyte-stimulating hormone receptor, a well-known melanoma susceptibility gene. Previous studies showed that MGRN1 ...
Conditioned Medium from H2O2-Preconditioned Human Adipose-Derived Stem Cells Ameliorates UVB-Induced Damage to Human Dermal Fibroblasts
(MDPI, 2022-10-11)
Human skin exposure to ultraviolet B (UVB) radiation can result in acute photodamage through oxidative modifications of cellular components and biomolecules involved in the metabolism of dermal cells. Recently, the therapeutic ...
Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer
(Wiley, 2022)
[EN] Discoidin domain receptor 2 (DDR2) is arising as a promising therapeutic target in breast carcinoma (BC). The ability of DDR2 to bind to collagen promotes protumoral responses in cancer cells that influence the tumor ...
Silencing of Sinusoidal DDR1 Reduces Murine Liver Metastasis by Colon Carcinoma
(Nature, 2020-10-27)
Liver metastasis depends on the collagenous microenvironment generated by hepatic sinusoidal cells (SCs). DDR1 is an atypical collagen receptor linked to tumor progression, but whether SCs express DDR1 and its implication ...
Innate Lymphoid Cells in the Malignant Melanoma Microenvironment
(MDPI, 2020-10-29)
The role of innate lymphoid cells (ILCs) in cancer progression has been uncovered in recent years. ILCs are classified as Type 1, Type 2, and Type 3 ILCs, which are characterized by the transcription factors necessary for ...
Ocoxin osagarri naturalaren eragin antitumorala pankreako minbiziko eta kolon-ondesteko minbiziaren metastasi hepatikoko eredu esperimentaletan.
(2020-12-22)
Pankreako minbiziak eta kolon-ondesteko minbiziaren metastasi hepatikoak heriotza ugari eragiten dituzte urtero. Hauek tratatzeko erabiltzen den teknika nagusienetariko bat kimioterapia da, zeinak pazienteengan zehar-efektu ...
Ocoxin as a complement to first line treatments in cancer
(Ivyspring International Publisher, 2021)
Chemotherapy and radiotherapy are the most frequent treatment for patients suffering from malignant progression of cancer. Even though new treatments are now being implemented, administration of these chemotherapeutic ...
Arming NK cells with chimeric antigen receptors (CARs) for treatment of refractory and/or relapsed hematological cancers: preclinical study to determine the best cell source.
(2020-02-10)
Acute Lymphoblastic Leukemia (ALL) and Chronic Lymphocytic Leukemia (CLL) are the most prevalent hematological cancers in children and elder patients respectively. Sometimes, standard treatments are not enough for curing ...
Estimulación termoalgésica controlada para explorar nuevos biomarcadores de la percepción del dolor.
(2023-12-12)
¿Es posible que las ondas eléctricas del cerebro (registradas mediante EEG) y su interacción con las hemodinámicas (registradas mediante PPG) puedan determinar de alguna manera situaciones de dolor progresivo? La sinergia ...
Characterization of a mouse model of autism. Focus on the excitatory/inhibitory and dopaminergic pathways
(2023-10-27)
El Trastorno del Espectro Autista (TEA) es una condición del neurodesarrollo que presenta diversos síntomas, entre los que destacan los déficits en comunicación y comportamiento social y la presencia de movimientos ...