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Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs
(BioMed Central, 2020-11-09)
Background: Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo development. ...
Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade
(Frontiers Media, 2022-04-21)
Increase of deposits of amyloid beta peptides in the extracellular matrix is landmark during Alzheimer's Disease (AD) due to the imbalance in the production vs. clearance. This accumulation of amyloid beta deposits triggers ...
Electrical features of the diabetic myocardium. Arrhythmic and cardiovascular Safety considerations in diabetes
(Frontiers Media, 2021-07-08)
[EN] Diabetes is a chronic metabolic disease characterized by hyperglycemia in the absence
of treatment. Among the diabetes-associated complications, cardiovascular disease is
the major cause of mortality and morbidity ...
Kv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats
(Springer, 2023-02)
Purpose Kv1.3 channel regulates the activity of lymphocytes, macrophages, or adipose tissue and its blockade reduces inflammatory cytokine secretion and improves insulin sensitivity in animals with metabolic syndrome and ...
Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
(MDPI, 2022-11-10)
Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid ...
Molecular and Electrophysiological Role of Diabetes-Associated Circulating Inflammatory Factors in Cardiac Arrhythmia Remodeling in a Metabolic-Induced Model of Type 2 Diabetic Rat
(MDPI, 2021-06-25)
Background: Diabetic patients have prolonged cardiac repolarization and higher risk of arrhythmia. Besides, diabetes activates the innate immune system, resulting in higher levels of plasmatic cytokines, which are described ...
Effects of Kv1.3 inhibition in type 2 diabetes-induced cardiac electrical remodeling.
(2021-07-13)
Background: Diabetic patients have prolonged cardiac repolarization and a higher risk ofarrhythmia. Besides, diabetes activatesthe innate immune system, resulting in higher levels of plasmatic proinflammatory cytokinessuch ...
Influencia de las nulisomías espermáticas en la infertilidad: caracterización proteómica e identificación de biomarcadores diagnóstico y de selección.
(2023-02-02)
La infertilidad humana es un problema social que afecta a aproximadamente al 15% de la población mundial debiéndose en el 50% de los casos a un factor masculino. Son causa de infertilidad masculina los fallos durante la ...
NEDDylation, a versatile mechanism involved in Liver Disease and COVID-19
(2023-02-17)
Las modificaciones postraduccionales (MPTs) son un conjunto de modificaciones covalentes y reversibles que sufren las proteínas tras su biosíntesis, considerándose un mecanismo relevante en la diversificación funcional, ...
Hybrid 3D Printed and Electrospun Multi-Scale Hierarchical Polycaprolactone Scaffolds to Induce Bone Differentiation
(MDPI, 2022-12-19)
Complex scaffolds composed of micro- and nano-structures are a key target in tissue engineering and the combination of sequential 3D printing and electrospinning enables the fabrication of these multi-scale structures. In ...