Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
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Date
2022-11-10Author
Martín Fernández, Marta
Arroyo, Víctor
Carnicero, Carmen
Sigüenza, Rebeca
Busta, Reyes
Mora, Natalia
Antolín, Beatriz
Tamayo, Eduardo
Aspichueta Celaá, Patricia
Carnicero Frutos, Irene
Gonzalo Benito, Hugo
Aller de la Fuente, Rocio
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Antioxidants 11(11) : (2022) // Article ID 2217
Abstract
Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack of a non-invasive and reliable methods for the diagnosis of non-alcoholic steatohepatitis (NASH), it is important to find serum markers that are capable of discriminating or defining patients with this stage of NASH. Blood samples were obtained from 152 Caucasian subjects with biopsy-proven NAFLD due to persistently elevated liver enzyme levels. Metabolites representative of oxidative stress were assessed. The findings derived from this work revealed that NAFLD patients with a NASH score of ≥ 4 showed significantly higher levels of lipid peroxidation (LPO). Indeed, LPO levels above the optimal operating point (OOP) of 315.39 μM are an independent risk factor for presenting a NASH score of ≥ 4 (OR: 4.71; 95% CI: 1.68–13.19; p = 0.003). The area under the curve (AUC = 0.81, 95% CI = 0.73–0.89, p < 0.001) shows a good discrimination ability of the model. Therefore, understanding the molecular mechanisms underlying the basal inflammation present in these patients is postulated as a possible source of biomarkers and therapeutic targets in NASH.
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