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TWEAK/Fn14 Signaling Is Required for Liver Regeneration after Partial Hepatectomy in Mice
(Public Library of Science, 2014-01)
Background & Aims: Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of ...
The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population
(Public Library Science, 2014-08-05)
We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population ...
Gene Expression Profiling in Limb-Girdle Muscular Dystrophy 2A
(Public Library of Science, 2008-11-18)
Limb-girdle muscular dystrophy type 2A (LGMD2A) is a recessive genetic disorder caused by mutations in calpain 3 (CAPN3). Calpain 3 plays different roles in muscular cells, but little is known about its functions or in ...
Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation
(Public Library Science, 2015-08-05)
We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate ...
Viability Conditions for a Compartmentalized Protometabolic System: A Semi-Empirical Approach
(Public Library Science, 2012-06)
In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. ...
Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1
(Public Library Science, 2014-07-18)
Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 activation is a complex process that involves translocation from the ...
Evaluation of Fentanyl Disposition and Effects in Newborn Piglets as an Experimental Model for Human Neonates
(Public Library Science, 2014-03-04)
Background: Fentanyl is widely used off-label in NICU. Our aim was to investigate its cerebral, cardiovascular and pulmonary effects as well as pharmacokinetics in an experimental model for neonates.
Methods: Fentanyl ...
Towards Application of One-Class Classification Methods to Medical Data
(Hindawi Publishing, 2014)
In the problem of one-class classification (OCC) one of the classes, the target class, has to be distinguished from all other possible objects, considered as nontargets. In many biomedical problems this situation arises, ...
The Voltage-Gated Sodium Channel Na(v)1.8 Is Expressed in Human Sperm
(Public Library of Science, 2013-09)
The role of Na+ fluxes through voltage-gated sodium channels in the regulation of sperm cell function remains poorly understood. Previously, we reported that several genes encoding voltage-gated Na+ channels were expressed ...
Feature Selection for Speech Emotion Recognition in Spanish and Basque: On the Use of Machine Learning to Improve Human-Computer Interaction
(Public Library Science, 2014-10-03)
Study of emotions in human-computer interaction is a growing research area. This paper shows an attempt to select the most significant features for emotion recognition in spoken Basque and Spanish Languages using different ...