UPV-EHU ADDI
  • Back
    • English
    • Español
    • Euskera
  • Login
  • English 
    • English
    • Español
    • Euskera
  • FAQ
View Item 
  •   Home
  • INVESTIGACIÓN
  • Artículos, Comunicaciones, Libros
  • Artículos
  • View Item
  •   Home
  • INVESTIGACIÓN
  • Artículos, Comunicaciones, Libros
  • Artículos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Viability Conditions for a Compartmentalized Protometabolic System: A Semi-Empirical Approach

Thumbnail
View/Open
journal.pone.0039480.pdf (1.354Mb)
Date
2012-06
Author
Piedrafita, Gabriel
Ruiz Mirazo, Pedro
Monnard, Pierre-Alain
Cornish-Bowden, Athel
Montero, Francisco
Metadata
Show full item record
PLoS One 7(6) : (2012) // e39480
URI
http://hdl.handle.net/10810/11570
Abstract
In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions under which a reaction network with a catalytically closed organization (more specifically, an (M, R)-system) would overcome the potential problem of self-suffocation that arises from the limited accessibility of nutrients to its internal reaction domain. The relationship between the permeability of the membrane, the lifetime of the key catalysts and their efficiency (reaction rate enhancement) turns out to be critical. In particular, we show how permeability values constrain the characteristic time scale of the bounded protometabolic processes. From this concrete and illustrative example we finally extend the discussion to a wider evolutionary context.
Collections
  • Artículos

DSpace software copyright © 2002-2015  DuraSpace
OpenAIRE
OpenAIRE
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesDepartamentos (cas.)Departamentos (eus.)SubjectsThis CollectionBy Issue DateAuthorsTitlesDepartamentos (cas.)Departamentos (eus.)Subjects

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
OpenAIRE
OpenAIRE