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Tuning the dimensionality of supramolecular functional materials based on the rational design of biomolecules
(2024-01-26)
El diseño racional desecuencias peptídicas y proteínas ha permitido el desarrollo de materiales híbridos coensamblados unidimensionales o bidimensionales. La dimensionalidad adoptada por el material depende directamente ...
Study of human and mouse dermal fibroblast heterogeneity by single-cell RNA sequencing.
(2023-10-18)
The skin is a complex vital organ composed of several layers. The middle layer, the dermis, is mainly composed of fibroblasts that produce the extracellular matrix (ECM) providing structural support. Recent research using ...
Development of a high-throughput platform to measure plasmid transfer frequency
(Frontiers Media, 2023-10)
Antibiotic resistance represents one of the greatest threats to global health. The spread of antibiotic resistance genes among bacteria occurs mostly through horizontal gene transfer via conjugation mediated by plasmids. ...
Molecular recognition of the HIV-1 neutralizing MPER epitope reconstituted in membranes. Contribution of lipid composition and transmembrane domain inclusion.
(2022-04-08)
GIBaren gainazalean kokatzen den Env proteina da birusaren infekzioa hasteko gertatu behar den birusaren eta itu zelularen mintzen arteko fusioa eragiten duena eta immunitate sistemarentzako eskuragarri dagoen proteina ...
Regulation of macrophage and preadipocyte proliferation and migration by C1P
(2022-03-25)
Chronic inflammatory diseases are the most significant cause of death in the world. Indeed, according to the World Health Organization (WHO), 3 out of 5 people die due to chronic inflammatory diseases such as stroke, chronic ...
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
(Nature Publishing Group, 2019-12)
N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ...
Validation of 31P-NMR spectroscopy as analytical method for assessing metabolic landscape of mouse liver
(2024-02-02)
Dada la complejidad del metabolismo hepático, es imprescindible reducir dicha complejidad al mínimo de información prescindible. En este contexto, se propone que el metabolismo puede describirse cuantitativamente centrándose ...
Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane
(Nature, 2023-11)
Bacterial competition is a significant driver of toxin polymorphism, which allows continual compensatory evolution between toxins and the resistance developed to overcome their activity. Bacterial Rearrangement hot spot ...
The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
(Nature, 2022)
The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to ...
Advanced nanoparticles: from single-modality contrast to theranostics in preclinical applications.
(2024-02-16)
El trabajo presentado en esta tesis se centra en el desarrollo de sondas de imágenes moleculares basadas en nanopartículas, diseñadas para su utilización en la Resonancia Magnética (MRI) y la Tomografía por Emisión de ...