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Implication of ceramide 1-phosphate in obesity-associated processes. Role of PEMT
(2016-01-22)
Obesity is the most common metabolic disease in developed nations and has become a global epidemic in recent years. Therefore, understanding the molecular mechanisms that regulate obesity-associated processes, such as cell ...
Molecular Techniques for Dicistrovirus Detection without RNA Extraction or Purification
(Hindawi Publishing Corporation, 2013)
Dicistroviridae is a new family of small, nonenveloped, and +ssRNA viruses pathogenic to both beneficial arthropods and insect pests as well. Triatoma virus (TrV), a dicistrovirus, is a pathogen of Triatoma infestans ...
Multiscale modelization in a small virus: Mechanism of proton channeling and its role in triggering capsid disassembly
(Public Library Science, 2018-04)
In this work, we assess a previously advanced hypothesis that predicts the existence of ion channels in the capsid of small and non-enveloped icosahedral viruses. With this purpose we examine Triatoma Virus (TrV) as a case ...
Interaction between colicin A pore-forming domain and its cognate immunity protein
(2017-07-14)
La colicina A y en concreto el dominio formador de poros, pfColA es expresado por Escherichia coli y resulta tóxico para cepas relacionadas. Las bacterias productoras de la toxina expresan la proteína de inmunidad Cai que ...
Repurposing ciclopirox as a pharmacological chaperone active against congenital erythropoietic porphyria.
(2018-10-19)
La porfiria eritropoyética congénita es una enfermedad rara autosómica recesiva producida por una actividad deficiente en la uroporfirinógeno III sintasa, la cuarta enzima de la ruta biosintética del grupo hemo. La enfermedad ...
Mechanistic details of apoptosis-regulatory proteins BAX and BFL1 at the membrane level
(2017-12-18)
La homeostasis de tejidos es considerado como el equilibrio entre la muerte y proliferación celular, y es por ello que su desregulación a menudo está asociada a diversas situaciones patológicas, tales como enfermedades ...
ICTV Virus Taxonomy Profile:PolycipiviridaeIngrida
(Microbiology Society, 2019-04)
Polycipiviridae is a family of picorna-like viruses with non-segmented, linear, positive-sense RNA genomes of approximately 10-12 kb. Unusually for viruses within the order Picornavirales, their genomes are polycistronic, ...
Lipid-lipid interactions in bilayers containing polar sphingolipids, ceramide and cholesterol.
(2019-04-11)
La presente tesis se ha centrado el estudio de las interacciones lípido-lípido asociadas a la segregación lateral de esfingolipidos y colesterol. Estos estudios se han llevado a cabo utilizando sistemas de membranas modelo ...
A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold
(Public Library Science, 2013-08)
Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous ...
Ceramide and ceramide 1-phosphate in health and disease
(BioMed Central, 2010-02)
Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the ...