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Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
(Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ...
Mycorrhizal-assisted phytoremediation and intercropping strategies improved the health of contaminated soil in a peri-urban area
(Frontiers Media, 2021-07-02)
[EN] Soils of abandoned and vacant lands in the periphery of cities are frequently subjected
to illegal dumping and can undergo degradation processes such as depletion of
organic matter and nutrients, reduced biodiversity, ...
Unveiling Magnesium homeostasis in liver diseases
(2022-10-24)
El Magnesio (Mg2+) es un micronutriente esencial en la dieta humana debido a su papel en diversosprocesos celulares y enzimáticos. En esta tesis hemos identificado cómo un desequilibrio en el contenidode Mg2+ en el hígado ...
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
(Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ...
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
(Springer Nature, 2022-02)
[EN] Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as a prostate cancer biomarker. This enzyme is predominantly ...
On the effect of cosolutes and crowders in the stability and kinetic properties of proteins
(2022-10-24)
[EN]It is known since long time that life is present in every environment on Earth, however, this fact results surprising, since some of such environments are characterized by conditions that seem to be incompatible with ...
Birth and Early Steps of the Organization of Biophysics in Spain
(MDPI, 2022-11-19)
In the 1960s, Biophysics was an unheard of scientific field in Spain, and even outside Spain, the distinction between Biophysics and Molecular Biology was not clear at the time. This paper describes briefly the developments ...
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
(Wiley, 2020-07-07)
[EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased
in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence
has been associated with age-dependent hepatosteatosis. ...
Development of biotin-based strategies to dissect the ubiquitin code.
(2022-12-15)
La naturaleza dinámica y reversible de las modificaciones post-traduccionales por parte de los miembros de la familia de la ubiquitina plantea importantes desafíos durante su investigación. En esta Tesis presentamos dos ...
Toward Diffusion Measurements of Colloidal Nanoparticles in Biological Environments by Nuclear Magnetic Resonance
(Wiley, 2020-09-20)
Protein corona formation on the surface of nanoparticles (NPs) is observed in situ by measuring diffusion coefficients of the NPs under the presence of proteins with a F-19 nuclear magnetic resonance (NMR) based methodology. ...