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Molecular Techniques for Dicistrovirus Detection without RNA Extraction or Purification
(Hindawi Publishing Corporation, 2013)
Dicistroviridae is a new family of small, nonenveloped, and +ssRNA viruses pathogenic to both beneficial arthropods and insect pests as well. Triatoma virus (TrV), a dicistrovirus, is a pathogen of Triatoma infestans ...
Multiscale modelization in a small virus: Mechanism of proton channeling and its role in triggering capsid disassembly
(Public Library Science, 2018-04)
In this work, we assess a previously advanced hypothesis that predicts the existence of ion channels in the capsid of small and non-enveloped icosahedral viruses. With this purpose we examine Triatoma Virus (TrV) as a case ...
Interaction between colicin A pore-forming domain and its cognate immunity protein
(2017-07-14)
La colicina A y en concreto el dominio formador de poros, pfColA es expresado por Escherichia coli y resulta tóxico para cepas relacionadas. Las bacterias productoras de la toxina expresan la proteína de inmunidad Cai que ...
Repurposing ciclopirox as a pharmacological chaperone active against congenital erythropoietic porphyria.
(2018-10-19)
La porfiria eritropoyética congénita es una enfermedad rara autosómica recesiva producida por una actividad deficiente en la uroporfirinógeno III sintasa, la cuarta enzima de la ruta biosintética del grupo hemo. La enfermedad ...
Mechanistic details of apoptosis-regulatory proteins BAX and BFL1 at the membrane level
(2017-12-18)
La homeostasis de tejidos es considerado como el equilibrio entre la muerte y proliferación celular, y es por ello que su desregulación a menudo está asociada a diversas situaciones patológicas, tales como enfermedades ...
ICTV Virus Taxonomy Profile:PolycipiviridaeIngrida
(Microbiology Society, 2019-04)
Polycipiviridae is a family of picorna-like viruses with non-segmented, linear, positive-sense RNA genomes of approximately 10-12 kb. Unusually for viruses within the order Picornavirales, their genomes are polycistronic, ...
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
(Nature, 2020-08-12)
Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The detection and quantification of apoptotic cells in vivo is hampered ...
Determinación estructural de virus con envuelta lipída mediante crio-microscopía electrónica.
(2020-02-10)
Viruses are parasitic biological agents that in the virion state contain differentmorphologies and assembly organisations. In some virions, a lipid membrane of cellularorigin is a structural component of the infectious ...
Implication of Ceramide Kinase/C1P in Cancer Development and Progression
(MDPI, 2022-01-04)
Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that ...
Searching for biomarkers of non-alcoholic fatty liver disease and metabolic syndrome
(2020-05-29)
El desarrollo de esta tesis doctoral ha aportado luz sobre los mecanismos que subyacen a la enfermedad del hígado graso no alcohólico (NAFLD por sus siglas en inglés), ya que los resultados han revelado la existencia de ...