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Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group
(Elsevier, 2022-02)
[EN] BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli (E.coli) asparaginase. Comparison of incidence of allergic reactions to pegylated ...
Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study
(Wiley, 2022-06)
[EN] Background White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well-known prognostic factor in acute lymphoblastic leukemia (ALL), but its biology, including impact of host genome ...
Lipid regulation of Atg8 family protein recruitment and membrane modulation of mitophagy and autophagic cell death
(2017-01-20)
Tesi lan honen aurkikuntzek, mitofagian zehar LC3/GABARAP familiako proteinen mitokondrioetarako errekrutatze-prozesuaren mekanismo molekularraren eta Atg8 proteinaren giza ortologoek giza lerro zelular ezberdinetan daukaten ...
The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
(MDPI, 2020-02-29)
The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of brain gangliosides) has been assayed by density gradient ...
Exploring Polar Headgroup Interactions Between Sphingomyelin and Ceramide with Infrared Spectroscopy
(Nature, 2020-10-19)
Ceramide is a major actor in the sphingolipid signaling pathway elicited by various kinds of cell stress. Under those conditions ceramide (Cer) is produced in the plasma membrane as a product of sphingomyelin (SM) hydrolysis, ...
Exploring HIV-1 lipid-interacting partners by chemical-based approaches.
(2022-06-07)
Esta tesis doctoral se ha centrado en el empleo de diferentes herramientas químicas desarrolladas para el estudio de interacciones lípido-proteína y proteína-proteína en el contexto del Virus de la Inmunodeficiencia Humana ...