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Understanding Aβ peptide binding to lipid membranes: A biophysical perspective
(MDPI, 2024-06-10)
Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer’s disease, the major cause of late-age dementia. ...
Bio-based hybrid nanocomposites as multifunctional sustainable materials for stone conservation
(Elsevier, 2023-08-23)
This study was aimed at developing a sustainable versatile bio-based epoxy-silica material to be potentially employed as hydrophobic and biocidal consolidating product in the field of stone conservation. For this purpose, ...
Bases estructurales del transporte de Mg2+ mediado por los factores homeostáticos CNNM2 y CNNM4, y de su interacción oncogénica con las fosfatasas PRL.
El Magnesio, segundo catión intracelular más abundante, es un ión imprescindible en diversas funciones vitales como la neurotransmisión, la conductancia cardiaca o la síntesis de ATP. Este papel biológico trascendental ...
Elucidating Angelman syndromes,s molecular mechanisms by identifying the substrates, interactors and counteracting DUBs of UBE3A
(2022-07-11)
Tesi honetan, aurretiaz Drosophila melanogaster eulian eta saguetan identifikatutako UBE3Aren balizko substratuak balioztatu ditugu, horretarako moldatutako purifikazio estrategia bat erabiliz ¿GFP pull-down estrategia¿. ...
Lipid-protein interactions in autophagy: Exploring the role of LC3/GABARAP-family members
(2022-07-19)
La autofagia es una vía de degradación conservada entre los eucariotas caracterizada por la formación de una vesícula de doble membrana (autofagosoma) alrededor de lo que se quiere degradar para su posterior eliminación ...
High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
(MDPI, 2022-05)
Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with critical roles during neurodevelopment, particularly within neural stem cells. Previous studies showed that high levels ...
Identification of novel drivers of cancer malignancy
(2024-03-11)
[EN]SRY-box transcription factor 9 (SOX9) is a critical developmental regulator that guides cell-fate decisions and maintenance of stem cells during development and adult homeostasis in a wide range of tissues, including ...
Mapping the diversity of trained immunity against live bacteria: plasticity of macrophage response in homeostasis and disease
(2024-03-21)
In the past decade, the existence of long-term consequences of the stimulation of innate immune cells has been recognized, resulting in divergent immune responses to secondary challenges. Trained immunity has redefined our ...
Porphyrin concentrations in health and disease: on the molecular definition of porphyria and COVID-19
(2024-03-18)
Diagnosing porphyria presents challenges due to its nonspecific clinical manifestations, necessitating diverse biochemical analyses. This study introduces an enzymatic approach aimed at elucidating the underlying molecular ...
Targeting PML in triple negative breast cancer elicits growth suppression and senescence
(Nature, 2020-04)
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a ...