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Predictive Modeling and Structure Analysis of Genetic Variants in Familial Hypercholesterolemia: Implications for Diagnosis and Protein Interaction Studies
(Springer Nature, 2023-10)
Purpose of Review Familial hypercholesterolemia (FH) is a hereditary condition characterized by elevated levels of low-
density lipoprotein cholesterol (LDL-C), which increases the risk of cardiovascular disease if left ...
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif
(Nature, 2024-01)
The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial and peroxisomal fission, but the regulatory mechanisms remain ambiguous. Here we find that a conserved, intrinsically disordered, six-residue ...
Improving the mechanical and biological functions of cell sheet constructs: The interplay of human-derived periodontal ligament stem cells, endothelial cells and plasma rich in growth factors
(Elsevier, 2024-05)
Objective
The aim of this study was to produce and characterize triple-layered cell sheet constructs with varying cell compositions combined or not with the fibrin membrane scaffold obtained by the technology of Plasma ...
On the antimicrobial properties and endurance of eugenol and 2-phenylphenol functionalized sol-gel coatings
(Elsevier, 2024-04)
Preventing microbiological surface contamination in public spaces is nowadays of high priority. The proliferation of a microbial infection may arise through air, water, or direct contact with infected surfaces. Chemical ...
Novel functions of Calmodulin in Kv7.2 regulation and co-translational folding
(2023-07-17)
CaM binds to the calcium responsive domain (CRD) of voltage-gated potassium channel 7.2 (Kv7.2), transmitting calcium signaling to control its pore gating. In addition, CaM affects other functions, such as trafficking to ...
MLb-LDLr: A Machine Learning Model for Predicting the Pathogenicity of LDLr Missense Variants
(Elsevier, 2021-11)
Untreated familial hypercholesterolemia (FH) leads to atherosclerosis and early cardiovascular disease. Mutations in the low-density lipoprotein receptor (LDLr) gene constitute the major cause of FH, and the high number ...
Enhanced phytoremediation of metal contaminated soils aimed at decreasing the risk of antibiotic resistance dissemination
(Frontiers Media, 2024)
The enhanced phytoremediation of metal contaminated soils holds great
promise for the recovery of soil health and functionality, while providing a
range of co-benefits, from an environmental and human health perspectiv ...
OptiMo-LDLr: an integrated In silico model with enhanced predictive power for LDL receptor variants, unraveling hot spot pathogenic residues
(Wiley, 2024-04)
Familial hypercholesterolemia (FH) is an inherited metabolic disease affecting cholesterol metabolism, with 90% of cases caused by mutations in the LDL receptor gene (LDLR), primarily missense mutations. This study aims ...
Development and integration of In Silico and In Vitro tools for comprehensive prediction and characterization of genetic variants in Familial Hypercholesterolemia and Hyperlipidemias
(2024-01-12)
El objetivo de mi tesis se centra en el desarrollo de técnicas in silico e in vitro para la predicción y caracterización de variantes causantes de hipercolesterolemia familiar e hiperlipemias. El uso de modelos y software ...