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Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease
(MDPI, 2018-11-01)
Cholesterol is an essential component of cell barrier formation and signaling transduction involved in many essential physiologic processes. For this reason, cholesterol metabolism must be tightly controlled. Cell cholesterol ...
Validation of LDLr Activity as a Tool to Improve Genetic Diagnosis of Familial Hypercholesterolemia: A Retrospective on Functional Characterization of LDLr Variants
(MDPI, 2018-06)
Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by high blood-cholesterol levels mostly caused by mutations in the low-density lipoprotein receptor (LDLr). With a prevalence as high as ...
Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin
(MDPI, 2018-12-04)
Adenylate cyclase toxin (ACT, CyaA) is one of the important virulence factors secreted by the whooping cough bacterium Bordetella pertussis, and it is essential for the colonization of the human respiratory tract by this ...
Determinación estructural de virión del Virus del mosaico de la sandia por crío-microscopía electrónica
(2018-09-14)
Los virus filamentosos flexibles constituyen uno de los mayores grupos de patógenos de plantas con un impacto en la agricultura muy relevante. Estos virus con genoma (+)ssRNA presentan viriones filamentosos flexibles con ...
Ubiquitylation Dynamics of the Clock Cell Proteome and TIMELESS During a Circadian Cycle
(Cell Press, 2018-05-22)
Circadian clocks have evolved as time-measuring molecular devices to help organisms adapt their physiology to daily changes in light and temperature. Transcriptional oscillations account for a large fraction of rhythmic ...
Physico-chemical interactions between compartment-forming lipids and other prebiotically relevant biomolecules
(EDP Sciences, 2014)
Lipids are essential constituents of contemporary living cells, serving as structural molecules that are necessary to form membranous compartments. Amphiphilic lipid-like molecules may also have contributed to prebiotic ...
Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes
(Elsevier, 2017-04)
We provide detailed datasets from our analysis of the proteins that associate with IL-2Rbeta and IL-2Rgamma in T-cells stimulated with IL-2 or IL-15 compared with resting T-cells, as identified by SILAC-based quantitative ...
SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies
(MDPI, 2021-05-27)
High plasma level of low-density lipoprotein (LDL) is the main driver of the initiation and progression of cardiovascular disease (CVD). Nevertheless, high-density lipoprotein (HDL) is considered an anti-atherogenic ...
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes
(MDPI, 2017-09-21)
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and ...
The role of the Wnt receptor frizzled-8 in prostate cancer pathogenesis.
(2018-11-30)
Wnt-11 es un miembro no canónico de la familia de Wnt que se observa altamente expresado en líneas celulares de cáncer de próstata, así como en tumores de próstata. Wnt-11 promueve la migración y la invasión celular lo que ...