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Histopatologian oinarritutako tratamendu kirurgikotik proteogenomikak gidatutako doitasunezko kirurgiara
(2021-06-29)
SARRERA: Urdaileko minbizia difusoaren (UMD) prebalentziak gora egin du pixkanaka, heste-motarekin berdindu arte. Arazo kliniko eta terapeutiko handiak sortzen ditu, orain arte erabilitako tratamenduei ez baitie ondo ...
Cannabinoid control of hippocampal functions: thewherematters
(Wiley, 2022-04)
In the brain, hippocampal circuits are crucial for cognitive performance (e.g., memory) and deeply affected in pathological conditions (e.g., epilepsy, Alzheimer). Specialized molecular mechanisms regulate different cell ...
Oligodendroglial Energy Metabolism and (re)Myelination
(MDPI, 2021-03-13)
Central nervous system (CNS) myelin has a crucial role in accelerating the propagation of action potentials and providing trophic support to the axons. Defective myelination and lack of myelin regeneration following ...
Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
(Cell Press, 2020-08-18)
A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid ...
Synucleinopathy alters nanoscale organization anddiffusion in the brain extracellular space throughhyaluronan remodeling
(Nature, 2020-07-10)
In recent years, exploration of the brain extracellular space (ECS) has made remarkable progress, including nanoscopic characterizations. However, whether ECS precise conformation is altered during brain pathology remains ...
Special Issue “Olfaction: From Genes to Behavior”
(MDPI, 2020-06-15)
The senses dictate how the brain represents the environment, and this representation is the basis of how we act in the world [...]
Super-Resolution STED Microscopy in live Brain Tissue
(Elsevier, 2021-08)
STED microscopy is one of several fluorescence microscopy techniques that permit imaging at higher spatial resolution than what the diffraction-limit of light dictates. STED imaging is unique among these super-resolution ...
Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer's Disease
(Frontiers Media, 2022-04)
The distribution and roles of the cannabinoid CB2 receptor in the CNS are still a matter of debate. Recent data suggest that, in addition to its presence in microglial cells, the CB2 receptor may be also expressed at low ...
Genetically modified macrophages accelerate myelin repair
(Wiley, 2022-08-08)
[EN] Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in ...
Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division
(Frontiers Media, 2020-08-14)
A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus of most mammals. These NSCs generate also astrocytes naturally and are capable ...