Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
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Date
2020-08-18Author
Oliveira da Cruz, Jose F.
Busquets García, Arnau
Zhao, Zhe
Varilh, Marjorie
Lavanco, Gianluca
Bellocchio, Luigi
Robin, Laurie
Cannich, Astrid
Julio Kalajzić, Francisca
Lesté Lasserre, Thierry
Maître, Marlène
Drago, Filippo
Marsicano, Giovanni
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Cell Reports 32(7) : (2020) // Article ID 108046
Abstract
A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal intemeurons determines episodic-like memory consolidation by linking dopamine D-1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB(1)Rs in D-1-positive cells (D-1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB(1)Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D-1-dependent manner.
This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.