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Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
(SpringerNature, 2022)
[EN] Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying ...
Demencia frontotemporal: genética, estudio evolutivo clínico, neuropsicológico y conductual
(2022-09-30)
La demencia frontotemporal (DFT) segunda forma de demencia de inicio temprano tras la enfermedad de Alzheimer (EA) representa un grupo heterogéneo de trastornos que en los últimos años está experimentando extraordinarios ...
Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults
(Frontiers Media, 2022-06)
Evidence suggests that lightly myelinated cortical regions are vulnerable to aging and Alzheimer's disease (AD). However, it remains unknown whether plasma markers of amyloid and neurodegeneration are related to deficits ...
Assessment of Pharmaceutical Mixture (Ibuprofen, Ciprofloxacin And Flumequine) Effects to the Crayfish Procambarus Clarkii: a Multilevel Analysis (Biochemical, Transcriptional and Proteomic Approaches)
(Elsevier, 2021-05-29)
The knowledge about the effects of pharmaceuticals on aquatic organisms has been increasing in the last decade. However, due to the variety of compounds presents in the aquatic medium, exposure scenarios and exposed ...
Longitudinal outcome of attenuated positive symptoms, negative symptoms, functioning and remission in people at clinical high risk for psychosis: a meta-analysis
(Elsevier, 2021-06-16)
[EN] Background: Little is known about clinical outcomes other than transition to psychosis in people at Clinical High-Risk for psychosis (CHR-P). Our aim was to comprehensively meta-analytically evaluate for the first ...
Cerebro, lipidómica y alzheimer: estudio de biomarcadores y neuroimagen en personas sanas.
(2020-07-16)
El objetivo general de esta tesis es ampliar el conocimiento sobre la fisiopatología de la EA e investigar la posible interrelación existente entre tres hechos biológicos cerebrales que podrían estar involucrados en los ...
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?
(MDPI, 2021-09-27)
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disorder of unknown physiopathology with multisystemic repercussions, framed in ICD-11 under the heading of neurology (8E49). There is no specific test to ...
Murine femur micro-computed tomography and biomechanical datasets for an ovariectomy-induced osteoporosis model
(Nature Research, 2021-09-15)
The development of new effective and safer therapies for osteoporosis, in addition to improved diagnostic and prevention strategies, represents a serious need in the scientific community. Micro-CT image-based analyses in ...
Glyceryl trinitrate in first-episode psychosis unmedicated with antipsychotics: A randomised controlled pilot study
(Sage, 2020-08)
There is a pressing need for new classes of treatment for psychosis. A key therapeutic target for novel compounds is the NMDA receptor, which may be modulated by nitric oxide donors such as sodium nitroprusside (SNP). ...
Universal and selective interventions to promote good mental health in young people: Systematic review and meta-analysis
(Elsevier, 2020-12)
Promotion of good mental health in young people is important. Our aim was to evaluate the consistency and magnitude of the efficacy of universal/selective interventions to promote good mental health. A systematic ...