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Revisiones sistemáticas y meta-análisis en modelos animales para la investigación traslacional de patologías psiquiátricas.
(2021-09-16)
El trabajo se centra en el estudio de la eficacia de antinflamatorios en modelos animales de depresión como acercamiento a la investigación traslacional en su posible aplicación como intervención terapéutica en depresión. ...
True-color 3D rendering of human anatomy using surface-guided color sampling from cadaver cryosection image data: A practical approach Jon Jatsu Azkue
(Wiley, 2022-08)
Three-dimensional computer graphics are increasingly used for scientific visualization and for communicating anatomical knowledge and data. This study presents a practical method to produce true-color 3D surface renditions ...
Damage-responsive neuro-glial clusters coordinate the recruitment of dormant neural stem cells in Drosophila
(Elsevier, 2022-07)
[EN] Recruitment of stem cells is crucial for tissue repair. Although stem cell niches can provide important signals, little is known about mechanisms that coordinate the engagement of disseminated stem cells across an ...
Generación de distintas cepas de priones recombinantes como herramienta para el estudio del alplegamiento espontáneo en las enfermedades priónicas
(2021-09-17)
La isoforma malplegada (PrPSc) de la proteína del prion celular (PrPC), es el agente causal de las Encefalopatías Espongiformes Transmisibles (EET), un conjunto de desórdenes neurodegenerativos mortales que afectan a ...
The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance
(Oxford University Press, 2022-08)
Background Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is ...
Examining the variability of neurocognitive functioning in individuals at clinical high risk for psychosis: a meta-analysis
(Springer, 2022-05-12)
This study aims to meta-analytically characterize the presence and magnitude of within-group variability across neurocognitive functioning in young people at Clinical High-Risk for psychosis (CHR-P) and comparison groups. ...
Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort
(Elsevier, 2022-06)
[EN] Objective: Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common ...
Ultrastructural and physiological studies on the cannabinoid CB1 receptor localized in astroglia.
(2021-10-28)
The cannabinoid CB1 receptor-mediated functions in astrocytes are highly dependent on the CB1 receptor
distribution in these glial cells relative to neuronal sites, particularly at the nearby synapses under normal
or ...
Suicidal behaviour and cognition: A systematic review with special focus on prefrontal deficits
(Elsevier, 2021-01-01)
BACKGROUND: Suicide is a major health concern worldwide, thus, identifying risk factors would enable a more comprehensive understanding and prevention of this behaviour. Neuropsychological alterations could lead to ...
Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia
(Nature Research, 2022-01-10)
[EN] Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control ...